TY - JOUR
T1 - Survival after autologous versus allogeneic transplantation in patients with relapsed and refractory Hodgkin lymphoma
AU - Fakhri, Bita
AU - Yilmaz, Elif
AU - Gao, Feng
AU - Ambinder, Richard F.
AU - Jones, Richard
AU - Bartlett, Nancy L.
AU - Cashen, Amanda
AU - Wagner-Johnston, Nina
N1 - Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - For relapsed Hodgkin lymphoma, salvage chemotherapy followed by auto-HCT is the standard of care. It is important to identify subpopulations who could benefit from allo-HCT. This retrospective analysis included 277 patients with rrHL who underwent first transplant with auto-HCT or allo-HCT between 2007–2017. Patients in the auto-HCT cohort (N = 218) were older, more likely to be in CR at the time of transplant and receive maintenance therapy post-transplant. Patients who underwent allo-HCT (N = 59) had a higher MSKCC relapse score. Factors associated with an inferior PFS and OS included early relapse, advanced stage, extranodal involvement and not achieving CR following salvage chemotherapy. After controlling for these 4 risk factors and MSKCC score, PFS (p = 0.112) or OS (p = 0.256) was not affected by the choice of transplant. In patients with ≥ 3 high risk features, the 4-year PFS was 51% in the allo-HCT vs. 39% (p = 0.107) in the auto-HCT cohort.
AB - For relapsed Hodgkin lymphoma, salvage chemotherapy followed by auto-HCT is the standard of care. It is important to identify subpopulations who could benefit from allo-HCT. This retrospective analysis included 277 patients with rrHL who underwent first transplant with auto-HCT or allo-HCT between 2007–2017. Patients in the auto-HCT cohort (N = 218) were older, more likely to be in CR at the time of transplant and receive maintenance therapy post-transplant. Patients who underwent allo-HCT (N = 59) had a higher MSKCC relapse score. Factors associated with an inferior PFS and OS included early relapse, advanced stage, extranodal involvement and not achieving CR following salvage chemotherapy. After controlling for these 4 risk factors and MSKCC score, PFS (p = 0.112) or OS (p = 0.256) was not affected by the choice of transplant. In patients with ≥ 3 high risk features, the 4-year PFS was 51% in the allo-HCT vs. 39% (p = 0.107) in the auto-HCT cohort.
KW - Autologous hematopoietic cell transplantation
KW - allogeneic hematopoietic cell transplantation
KW - relapsed Hodgkin lymphoma
UR - http://www.scopus.com/inward/record.url?scp=85106266945&partnerID=8YFLogxK
U2 - 10.1080/10428194.2021.1927016
DO - 10.1080/10428194.2021.1927016
M3 - Article
C2 - 33988071
AN - SCOPUS:85106266945
SN - 1042-8194
VL - 62
SP - 2408
EP - 2415
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 10
ER -