TY - JOUR
T1 - Survey of nonsusceptible nasopharyngeal streptococcus pneumoniae isolates in children attending day-care centers in Brazil
AU - Franco, Caritas M.
AU - Andrade, Ana Lucia S.
AU - Andrade, João G.
AU - E Silva, Simonne Almeida
AU - Oliveira, C. Renato M.
AU - Pimenta, Fabiana C.
AU - Lamaro-Cardoso, Juliana
AU - Brandão, Angela P.
AU - Almeida, Samanta C.G.
AU - Calix, Juan J.
AU - Nahm, Moon H.
AU - De Cunto Brandileone, Maria Cristina
N1 - Funding Information:
Supported by the Brazilian Council for Research and Development/CNPq ( 473187/2004-3, 482646/2007-1 ), the Secretariat of Health of Goiânia Municipality , and a grant from the US NIH ( AI-31473 ) to MHN. AL Andrade ( 309196/2007-8 ), MC Brandileone ( 301340/2007-2 ), and FC Pimenta ( 473880/2006-7 ) are fellowships from the CNPq.
PY - 2010/1
Y1 - 2010/1
N2 - A survey of nasopharyngeal carriage of penicillin nonsusceptible pneumococcal (PNSp) isolates was conducted among 1192 children attending 62 day care centers in Brazil, where pneumococcal vaccination has not been routinely introduced. Nasopharyngeal pneumococcal carriage was detected in 686 (57.6%) infants, and 178 (25.9%) of them carried PNSp isolates. Being less than 24 months of age, hospitalization in the previous 3 months, and recurrent acute otitis media were independently associated with PNSp. Serotypes 14, 23F, 19A, 6A, 6B and 19F were the most common serotype isolated accounting for 80% of the PNSp. A high proportion (35/332) of non-(sero)typeable isolates was detected, 62.9% of them PNSp. Serotypes coverage projected for the pneumococcal conjugate vaccine (PCV) 13-valent vaccine (72%) was significantly higher compared with PCV7 (58.4%) and PCV 10-valent vaccine (59.3%).
AB - A survey of nasopharyngeal carriage of penicillin nonsusceptible pneumococcal (PNSp) isolates was conducted among 1192 children attending 62 day care centers in Brazil, where pneumococcal vaccination has not been routinely introduced. Nasopharyngeal pneumococcal carriage was detected in 686 (57.6%) infants, and 178 (25.9%) of them carried PNSp isolates. Being less than 24 months of age, hospitalization in the previous 3 months, and recurrent acute otitis media were independently associated with PNSp. Serotypes 14, 23F, 19A, 6A, 6B and 19F were the most common serotype isolated accounting for 80% of the PNSp. A high proportion (35/332) of non-(sero)typeable isolates was detected, 62.9% of them PNSp. Serotypes coverage projected for the pneumococcal conjugate vaccine (PCV) 13-valent vaccine (72%) was significantly higher compared with PCV7 (58.4%) and PCV 10-valent vaccine (59.3%).
KW - Day care centers
KW - Nasopharyngeal carriage
KW - Nonsusceptible pneumococcal
KW - Pneumococcal carriage
KW - Pneumococcal serotypes
KW - Vaccine coverage
UR - http://www.scopus.com/inward/record.url?scp=74049164872&partnerID=8YFLogxK
U2 - 10.1097/INF.0b013e3181af7e90
DO - 10.1097/INF.0b013e3181af7e90
M3 - Article
C2 - 19935117
AN - SCOPUS:74049164872
SN - 0891-3668
VL - 29
SP - 77
EP - 79
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 1
ER -