Surgical therapy for corneal epithelial stem cell deficiency

Mei Chuan Yang, Andrew J.W. Huang, Steven Yeh, Stephen C. Pflugfelder

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The importance of limbal stem cells for maintenance of corneal clarity has been well documented. Stem cells renew the corneal epithelium by generating transient amplifying cells. The transient amplifying cells proliferate to become postmitotic cells, which mature into terminally differentiated cells. Terminally differentiated cells migrate centripetally from the limbus and peripheral cornea to the central cornea and then move from the basal to superficial layers. This renewing capacity resurfaces the corneal epithelium by maintaining the balance between loss of superficial epithelial cells and supplementation from limbal stem cells.

Original languageEnglish
Title of host publicationDry Eye and Ocular Surface Disorders
PublisherCRC Press
Number of pages22
ISBN (Electronic)9780849378201
ISBN (Print)9780824747022
StatePublished - Jan 1 2004


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