The importance of limbal stem cells for maintenance of corneal clarity has been well documented. Stem cells renew the corneal epithelium by generating transient amplifying cells. The transient amplifying cells proliferate to become postmitotic cells, which mature into terminally differentiated cells. Terminally differentiated cells migrate centripetally from the limbus and peripheral cornea to the central cornea and then move from the basal to superficial layers. This renewing capacity resurfaces the corneal epithelium by maintaining the balance between loss of superficial epithelial cells and supplementation from limbal stem cells.
|Title of host publication||Dry Eye and Ocular Surface Disorders|
|Number of pages||22|
|State||Published - Jan 1 2004|