Surgical management of islet-cell adenoma in infancy

R. Hampton Rich, Louis P. Dehner, Kota Okinaga, Larry C. Deeb, Robert A. Ulstrom, Arnold S. Leonard

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Persistent neonatal hypoglycemia is a potentially serious condition which should be recognized promptly, investigated thoroughly, and treated expeditiously. Islet-cell adenoma causing hypoglycemia in infancy is very unusual. Only 23 cases have been reported in the literature. This report documents eight cases of our own and summarizes diagnostic methods, proper medical preparation, and fundamental surgical management. Prompt surgical intervention is emphasized, as this will relieve hypoglycemia and may be important in preventing irreversible central nervous system damage. We are of the opinion that any infant with unremitting hypoglycemia, a high corrected insulin/glucose ratio, and failure to respond to maximum diazoxide therapy will require partial pancreatectomy. Identification of the adenoma at the time of operation is unlikely, and blind pancreatectomy and/or reoperation is not unusual.

Original languageEnglish
Pages (from-to)519-526
Number of pages8
Issue number4
StatePublished - Oct 1978


Dive into the research topics of 'Surgical management of islet-cell adenoma in infancy'. Together they form a unique fingerprint.

Cite this