Surgical Considerations of Hilar Cholangiocarcinoma

Blaire Anderson, M. B.Majella Doyle

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Cholangiocarcinoma is an aggressive malignancy of the extrahepatic bile ducts. Hilar lesions are most common. Patients present with obstructive jaundice and intrahepatic bile duct dilation. Cross-sectional imaging reveals local, regional, and distant extent of disease, with direct cholangiography providing tissue for diagnosis. The consensus of a multidisciplinary committee dictates treatment. Resection of the extrahepatic bile duct and ipsilateral hepatic lobe with or without vascular resection and transplantation after neoadjuvant protocol are options for curative treatment. The goal of surgery is to remove the tumor with negative margins. Patients with inoperable tumors or metastatic disease are best served with palliative chemoradiotherapy.

Original languageEnglish
Pages (from-to)601-617
Number of pages17
JournalSurgical Oncology Clinics of North America
Volume28
Issue number4
DOIs
StatePublished - Oct 2019

Keywords

  • Hepatic resection
  • Hilar cholangiocarcinoma
  • Liver transplantation
  • Vascular resection

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