Surfactant-associated protein D (SP-D) is a collagenous carbohydrate binding glycoprotein (collectin) that plays important roles in the lung's innate immune response to microbial and antigenic challenge. SP-D enhances the neutralization and/or clearance of a wide variety of microorganisms and microbial products, organic particulate antigens, and apoptotic cells, while inhibiting deleterious inflammatory and immune host responses. SP-D also contributes to the regulation of surfactant homeostasis, in part by reorganizing surfactant lipids, with resulting effects on epithelial uptake and turnover. Thus, it is likely that SP-D plays important roles in the pathogenesis of a wide variety of infectious, inflammatory, and immune-mediated lung disorders.

Original languageEnglish
Title of host publicationEncyclopedia of Respiratory Medicine, Second Edition
Number of pages8
ISBN (Electronic)9780081027240
ISBN (Print)9780081027233
StatePublished - Jan 1 2021


  • C-type lectin or lectins
  • Clara cells
  • Collectins
  • Host defense
  • Innate immunity
  • Surfactant
  • Surfactant protein A (SP-A)
  • Surfactant protein D (SP-D)
  • Type II epithelial cells


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