Abstract
Surfactant-associated protein D (SP-D) is a collagenous carbohydrate binding glycoprotein (collectin) that plays important roles in the lung's innate immune response to microbial and antigenic challenge. SP-D enhances the neutralization and/or clearance of a wide variety of microorganisms and microbial products, organic particulate antigens, and apoptotic cells, while inhibiting deleterious inflammatory and immune host responses. SP-D also contributes to the regulation of surfactant homeostasis, in part by reorganizing surfactant lipids, with resulting effects on epithelial uptake and turnover. Thus, it is likely that SP-D plays important roles in the pathogenesis of a wide variety of infectious, inflammatory, and immune-mediated lung disorders.
Original language | English |
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Title of host publication | Encyclopedia of Respiratory Medicine, Second Edition |
Publisher | Elsevier |
Pages | 115-122 |
Number of pages | 8 |
Volume | 1 |
ISBN (Electronic) | 9780081027240 |
ISBN (Print) | 9780081027233 |
DOIs | |
State | Published - Jan 1 2021 |
Keywords
- C-type lectin or lectins
- Clara cells
- Collectins
- Host defense
- Innate immunity
- Surfactant
- Surfactant protein A (SP-A)
- Surfactant protein D (SP-D)
- Type II epithelial cells