Surfactant protein D enhances clearance of influenza A virus from the lung in vivo

A. M. LeVine, J. A. Whitsett, K. L. Hartshorn, E. C. Crouch, T. R. Korfhagen

Research output: Contribution to journalArticlepeer-review

219 Scopus citations

Abstract

Mice lacking surfactant protein surfactant protein D (SP-D-/-) and wild-type mice (SP-D+/+) were infected with influenza A virus (IAV) by intranasal instillation. IAV infection increased the endogenous SP-D concentration in wild-type mice. SP-D-deficient mice showed decreased viral clearance of the Phil/82 strain of IAV and increased production of inflammatory cytokines in response to viral challenge. However, the less glycosylated strain of IAV, Mem/71, which is relatively resistant to SP-D in vitro, was cleared efficiently from the lungs of SP-D-/- mice. Viral clearance of the Phil/82 strain of IAV and the cytokine response were both normalized by the coadministration of recombinant SP-D. Since the airway is the usual portal of entry for influenza A virus and other respiratory pathogens, SP-D is likely to play an important role in innate defense responses to IAV.

Original languageEnglish
Pages (from-to)5868-5873
Number of pages6
JournalJournal of Immunology
Volume167
Issue number10
DOIs
StatePublished - Nov 15 2001
Externally publishedYes

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