Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia

Juliane Bubeck Wardenburg, Ravi J. Patel, Olaf Schneewind

Research output: Contribution to journalArticlepeer-review

248 Scopus citations

Abstract

A model of Staphylococcus aureus-induced pneumonia in adult, immunocompetent C57BL/6J mice is described. This model closely mimics the clinical and pathological features of pneumonia in human patients. Using this system, we defined a role for S. aureus strain Newman surface proteins and secreted exotoxins in pneumonia-related mortality.

Original languageEnglish
Pages (from-to)1040-1044
Number of pages5
JournalInfection and immunity
Volume75
Issue number2
DOIs
StatePublished - Feb 2007

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