Surface passivation of carbon nanoparticles with branched macromolecules influences near infrared bioimaging

Lina Wu, Micah Luderer, Xiaoxia Yang, Corban Swain, Huiying Zhang, Kate Nelson, Allen J. Stacy, Baozhong Shen, Gregory M. Lanza, Dipanjan Pan

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

A superior and commercially exploitable 'green synthesis' of optically active carbon nanoparticle (OCN) is revealed in this work. The naked carbon particles (<20 nm) were derived from commercial food grade honey. The fluorescence properties of these particles were significantly enhanced by utilizing hyberbranched polymer for surface passivation. A dramatic increase in near infrared emission was achieved compared to a linear polymer (PEG) coated carbon nanoparticles. Interestingly, as passivating agent becomes more extensively branched (pseudo generation 2 to 4), the average radiant efficiency amplifies considerably as a direct result of the increasing surface area available for light passivation. The particles showed negligible loss of cell viability in presence of endothelial cells in vitro. Preliminary in vivo experiment showed high contrast enhancement in auxiliary lymphnode in a mouse model. The exceptionally rapid lymphatic transport of these particles suggests that such an approach may offer greater convenience and reduced procedural expense, as well as improved surgical advantage as the patient is positioned on the table for easier resection.

Original languageEnglish
Pages (from-to)677-686
Number of pages10
JournalTheranostics
Volume3
Issue number9
DOIs
StatePublished - Sep 3 2013

Keywords

  • Carbon nanoparticle
  • Contrast agent
  • Hyperbranched polymer
  • Near infrared imaging
  • Surface passivation

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    Wu, L., Luderer, M., Yang, X., Swain, C., Zhang, H., Nelson, K., Stacy, A. J., Shen, B., Lanza, G. M., & Pan, D. (2013). Surface passivation of carbon nanoparticles with branched macromolecules influences near infrared bioimaging. Theranostics, 3(9), 677-686. https://doi.org/10.7150/thno.6535