TY - JOUR
T1 - Surface modification of PEEKs with cyclic peptides to support endothelialization and antithrombogenicity
AU - Young, Emma R.
AU - Martin, Cameron
AU - Ribaudo, Joseph G.
AU - Xia, Xiaochao
AU - Moritz, William R.
AU - Madira, Sarah
AU - Zayed, Mohamed A.
AU - Sacks, Justin M.
AU - Li, Xiaowei
N1 - Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2024/6
Y1 - 2024/6
N2 - Synthetic polymers are often utilized in the creation of vascular devices, and need to possess specific qualities to prevent thrombosis. Traditional strategies for this include surface modification of vascular devices through covalent attachment of substrates such as heparin, antiplatelet agents, thrombolytic agents, or hydrophilic polymers. One promising prosthetic material is polyether ether ketone (PEEK), which is utilized in various FDA-approved medical devices, including vascular and endovascular prostheses. We hypothesized that surface modification of biologically inert PEEK can help improve its endothelial cell affinity and reduce its thrombogenic potential. To evaluate this, we developed an effective surface-modification approach with unique cyclic peptides, such as CCHGGVRLYC and CCREDVC. We treated the PEEK surface with ammonia plasma, which introduced amine groups onto the PEEK surface. Subsequently, we were able to conjugate these peptides to the plasma-modified PEEKs. We observed that cyclic CCHGGVRLYC conjugated on prosthetic PEEK not only supported endothelialization, but minimized platelet adhesion and activation. This technology can be potentially applied for in vivo vascular and endovascular protheses to enhance their utility and patency.
AB - Synthetic polymers are often utilized in the creation of vascular devices, and need to possess specific qualities to prevent thrombosis. Traditional strategies for this include surface modification of vascular devices through covalent attachment of substrates such as heparin, antiplatelet agents, thrombolytic agents, or hydrophilic polymers. One promising prosthetic material is polyether ether ketone (PEEK), which is utilized in various FDA-approved medical devices, including vascular and endovascular prostheses. We hypothesized that surface modification of biologically inert PEEK can help improve its endothelial cell affinity and reduce its thrombogenic potential. To evaluate this, we developed an effective surface-modification approach with unique cyclic peptides, such as CCHGGVRLYC and CCREDVC. We treated the PEEK surface with ammonia plasma, which introduced amine groups onto the PEEK surface. Subsequently, we were able to conjugate these peptides to the plasma-modified PEEKs. We observed that cyclic CCHGGVRLYC conjugated on prosthetic PEEK not only supported endothelialization, but minimized platelet adhesion and activation. This technology can be potentially applied for in vivo vascular and endovascular protheses to enhance their utility and patency.
KW - Cyclic Peptides
KW - Endothelium
KW - Polyether Ether Ketone
KW - Surface Modification
KW - Vascular Anastomosis
UR - http://www.scopus.com/inward/record.url?scp=85188693497&partnerID=8YFLogxK
U2 - 10.1016/j.mtcomm.2024.108664
DO - 10.1016/j.mtcomm.2024.108664
M3 - Article
C2 - 38618226
AN - SCOPUS:85188693497
SN - 2352-4928
VL - 39
JO - Materials Today Communications
JF - Materials Today Communications
M1 - 108664
ER -