Surface immunoglobulin, the key surface receptor of B lymphocytes, undergoes ligand-dependent interaction with the cell cytoskeleton. The capacity of this receptor to associate with and activate the contractile apparatus mediates its unique influence on the lymphocyte physiology: membrane reorganization, chemotaxis, and receptor-ligand endocytosis. Features of this receptor-cytoskeleton interaction are probed with a simple but powerful detergent fractionation technique.

Original languageEnglish
Pages (from-to)2446-2451
Number of pages6
JournalFederation proceedings
Issue number8
StatePublished - 1983


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