Abstract
This chapter presents recent advances in the application of surface-enhanced Raman scattering (SERS) in bioimaging. It highlights several recent results as key examples that demonstrate the breadth of the applications of SERS. The chapter presents a brief introduction to Raman imaging using micro-Raman spectroscopy (μRS). This is followed by an overview of the instrumentation underlining the similarities and differences compared to conventional Raman spectroscopy. The chapter discusses the recent development in deep noninvasive Raman spectroscopy for probing diffusely scattering media, such as living tissue. It highlights the important considerations in the design and fabrication of bright SERS probes and experimental approaches of SERS-based bioimaging with selected examples. Finally, the chapter presents a brief summary and outlook of the SERS-based bioimaging.
| Original language | English |
|---|---|
| Title of host publication | Nanotechnology for Biomedical Imaging and Diagnostics |
| Subtitle of host publication | From Nanoparticle Design to Clinical Applications |
| Publisher | wiley |
| Pages | 325-346 |
| Number of pages | 22 |
| ISBN (Electronic) | 9781118873151 |
| ISBN (Print) | 9781118121184 |
| DOIs | |
| State | Published - Jan 30 2015 |
Keywords
- Raman instrumentation
- Raman reporter molecules
- Raman-based bioimaging
- Surface-enhanced Raman scattering (SERS)