TY - JOUR
T1 - Suppressive Therapy for Cryptococcal Meningitis
AU - Lange, Joep M.a.
AU - Reiss, Peter
AU - Larsen, Robert A.
AU - Williams, Kevin W.
AU - Powderly, William G.
AU - Saag, Michael S.
AU - Cloud, Gretchen A.
AU - Dismukes, William E.
PY - 1992/8/20
Y1 - 1992/8/20
N2 - To the Editor: In the valuable study by Powderly et al. (March 19 issue)1 comparing fluconazole with amphotericin B as suppressive therapy for cryptococcal meningitis in patients with the acquired immunodeficiency syndrome (AIDS), the authors state that relapse was not predicted by routine sampling of the cerebrospinal fluid in any of the patients with meningitis. It would be of great interest to know whether their frequent monitoring of serum cryptococcal-antigen titers helped predict relapses of cryptococcal disease during suppressive therapy for cryptococcal meningitis. Persistence of Cryptococcus neoformans in the prostate gland, a source of recurrent infection, is common after amphotericin…
AB - To the Editor: In the valuable study by Powderly et al. (March 19 issue)1 comparing fluconazole with amphotericin B as suppressive therapy for cryptococcal meningitis in patients with the acquired immunodeficiency syndrome (AIDS), the authors state that relapse was not predicted by routine sampling of the cerebrospinal fluid in any of the patients with meningitis. It would be of great interest to know whether their frequent monitoring of serum cryptococcal-antigen titers helped predict relapses of cryptococcal disease during suppressive therapy for cryptococcal meningitis. Persistence of Cryptococcus neoformans in the prostate gland, a source of recurrent infection, is common after amphotericin…
UR - http://www.scopus.com/inward/record.url?scp=0026720087&partnerID=8YFLogxK
U2 - 10.1056/NEJM199208203270814
DO - 10.1056/NEJM199208203270814
M3 - Letter
C2 - 1635575
AN - SCOPUS:0026720087
SN - 0028-4793
VL - 327
SP - 565
EP - 566
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 8
ER -