Abstract
BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.
Original language | English |
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Article number | e12056 |
Journal | Pulmonary Circulation |
Volume | 12 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2022 |
Keywords
- angiogenesis
- BMPR2
- hypoxia
- pulmonary hypertension