Superoxide dismutase and catalase in Toxoplasma gondii

L. David Sibley, Robin Lawson, Earl Weidner

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Catalase and superoxide dismutase detected in both RH and C strain Toxoplasma gondii tachyzoites were distinctly different in electrophoretic mobility from host cell enzymes. Catalase and superoxide dismutase activity levels were similar in both Toxoplasma strains and showed narrow pH optima around 8.0. Toxoplasma superoxide dismutase was resistant to cyanide but inhibited by azide or peroxide, consistent with an iron-containing enzyme typical of protozoan parasites. These enzymes may play a role in intracellular survival; however, they do not appear to be the basis for differences in virulence to mice.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalMolecular and Biochemical Parasitology
Volume19
Issue number1
DOIs
StatePublished - Apr 1986
Externally publishedYes

Keywords

  • Catalase
  • Oxygen intermediates
  • Superoxide dismutase
  • Toxoplasma gondii

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