TY - JOUR
T1 - Superiority of C-11 acetate compared with F-18 fluorodeoxyglucose in predicting myocardial functional recovery by positron emission tomography in patients with acute myocardial infarction
AU - Rubin, Patricia J.
AU - Lee, Dong Soo
AU - Dávila-Román, Victor G.
AU - Geltman, Edward M.
AU - Schechtman, Kenneth B.
AU - Bergmann, Steven R.
AU - Gropler, Robert J.
N1 - Funding Information:
From the Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology; and the Cardiovascular Division, Department of Internal Medicine, and the Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri. This work was supported in part by a grant from the Edward Mallinckrodt, Jr. Foundation, St. Louis, Missouri; and by grants HL17646 (SCOR in Coronary and Vascular Diseases] and HLl3851 from the National Institutes of Health, Bethesda, Ma “(:.. land. This study was performed durin Dr Gropler’s tenure as a C Inlclan-Sclentlst Awardee and Dr. D6v1 7 a-Rom6n’s tenure as a Minority Scientist Development Awardee, both from the American Heart Association. Manuscript received January 15, 1996; revised manuscript received and accepted June 4, 1996.
PY - 1996
Y1 - 1996
N2 - In patients with chronic coronary artery disease, preservation of myocardlal oxidative metabolism measured by positron emission tomography (PET) with 11C-acetate is a more accurate predictor of subsequent myocardial functional recovery than is maintenance of glucose metabolism estimated with 18F-fluorodeoxyglucose. However, whether measurements of myocardial oxidative metabolism are more accurate than measurements of glucose metabolism in predicting functional recovery in patients with recent myocardial infarction is unknown. Myocardial oxidative metabolism was measured within 10 days of infarction in 19 patients by analysis of the rate of myocardial clearance of 11C-acetate. Metabolism of glucose was assessed by analysis of the uptake of 18F-fluorodeoxyglucose. Criteria for prediction of the recovery of Function based on measurements of oxidative metabolism and glucose metabolism were compared. Threshold criteria with 11C-acetate exhibited superior positive and negative predictive values (89% and 73%, respectively) compared with the criteria of 18F-fluorodeoxyglucose (65% and 57%, respectively) (p <0.025). In addition, the magnitude of functional recovery after revascularization correlated with the severity of the metabolic abnormality present initially. In patients with recent myocardial infarction, the extent of functional recovery can be predicted accurately by measurement of regional oxidative metabolism by PET with 11C-acetate, and these measurements are superior to those of 18-fluorodeoxyglucose.
AB - In patients with chronic coronary artery disease, preservation of myocardlal oxidative metabolism measured by positron emission tomography (PET) with 11C-acetate is a more accurate predictor of subsequent myocardial functional recovery than is maintenance of glucose metabolism estimated with 18F-fluorodeoxyglucose. However, whether measurements of myocardial oxidative metabolism are more accurate than measurements of glucose metabolism in predicting functional recovery in patients with recent myocardial infarction is unknown. Myocardial oxidative metabolism was measured within 10 days of infarction in 19 patients by analysis of the rate of myocardial clearance of 11C-acetate. Metabolism of glucose was assessed by analysis of the uptake of 18F-fluorodeoxyglucose. Criteria for prediction of the recovery of Function based on measurements of oxidative metabolism and glucose metabolism were compared. Threshold criteria with 11C-acetate exhibited superior positive and negative predictive values (89% and 73%, respectively) compared with the criteria of 18F-fluorodeoxyglucose (65% and 57%, respectively) (p <0.025). In addition, the magnitude of functional recovery after revascularization correlated with the severity of the metabolic abnormality present initially. In patients with recent myocardial infarction, the extent of functional recovery can be predicted accurately by measurement of regional oxidative metabolism by PET with 11C-acetate, and these measurements are superior to those of 18-fluorodeoxyglucose.
UR - http://www.scopus.com/inward/record.url?scp=0030346253&partnerID=8YFLogxK
U2 - 10.1016/S0002-9149(96)00601-7
DO - 10.1016/S0002-9149(96)00601-7
M3 - Article
C2 - 8960580
AN - SCOPUS:0030346253
SN - 0002-9149
VL - 78
SP - 1230
EP - 1235
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 11
ER -