Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated Cells

Zhen Liu, Quynh P.H. Nguyen, Rashmi Nanjundappa, Nathalie Delgehyr, Alexandre Megherbi, Regan Doherty, James Thompson, Claire Jackson, Alexandra Albulescu, Yew M. Heng, Jane S. Lucas, Sharon D. Dell, Alice Meunier, Kirk Czymmek, Moe R. Mahjoub, Vito Mennella

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Liu, Nguyen et al. show that among hundreds of cilia of a multiciliated cell, there is one that differs from the others in structure, origin, and cellular position, and it participates in basal body alignment.

Original languageEnglish
Pages (from-to)224-236.e6
JournalDevelopmental cell
Volume55
Issue number2
DOIs
StatePublished - Oct 26 2020

Keywords

  • FIB-SEM
  • airway
  • appendages
  • basal bodies
  • basal foot
  • centrosome
  • cilia
  • electron microscopy
  • primary ciliary dyskinesia
  • quantitative imaging
  • super-resolution imaging

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