TY - JOUR
T1 - 99Tcm-MDP uptake by lymph nodes following tracer infiltration
T2 - Clinical and laboratory evaluation
AU - Wallis, Jerold W.
AU - Fisher, Susan
AU - Wahl, Richard L.
PY - 1987/5
Y1 - 1987/5
N2 - Uptake of bone scanning agents in non-osseous sites has been described in a variety of pathologic conditions including tumor metastases. We have seen several patients in which such uptake was proximal and ipsilateral to the injection site of99Tcm-rnethylene diphos- phonate, apparently in normal lymph nodes. To further investigate this phenomenon, it was studied in a rat model. Activity in popliteal nodes ipsilateral to the injection site was over 60-fold greater in the animals that received subcutaneous (s.q.) footpad injection compared to femoral IV injection. Ipsilateral popliteal node activity in the s.q. group was 159 times that of contralateral popliteal nodes, with an ipsilateral node to liver ratio of 184:1. In summary, dramatically increased uptake of99Tcm-MDP in normal lymph nodes ipsilateral and proximal to an extravasated injection has been demonstrated. An awareness of this phenomenon in the clinical setting can avoid confusion with pathologic forms of soft tissue uptake.
AB - Uptake of bone scanning agents in non-osseous sites has been described in a variety of pathologic conditions including tumor metastases. We have seen several patients in which such uptake was proximal and ipsilateral to the injection site of99Tcm-rnethylene diphos- phonate, apparently in normal lymph nodes. To further investigate this phenomenon, it was studied in a rat model. Activity in popliteal nodes ipsilateral to the injection site was over 60-fold greater in the animals that received subcutaneous (s.q.) footpad injection compared to femoral IV injection. Ipsilateral popliteal node activity in the s.q. group was 159 times that of contralateral popliteal nodes, with an ipsilateral node to liver ratio of 184:1. In summary, dramatically increased uptake of99Tcm-MDP in normal lymph nodes ipsilateral and proximal to an extravasated injection has been demonstrated. An awareness of this phenomenon in the clinical setting can avoid confusion with pathologic forms of soft tissue uptake.
UR - http://www.scopus.com/inward/record.url?scp=0023159012&partnerID=8YFLogxK
U2 - 10.1097/00006231-198705000-00006
DO - 10.1097/00006231-198705000-00006
M3 - Article
C2 - 3684101
AN - SCOPUS:0023159012
SN - 0143-3636
VL - 8
SP - 357
EP - 363
JO - Nuclear Medicine Communications
JF - Nuclear Medicine Communications
IS - 5
ER -