99mTc-diphosphonate uptake in skeletal muscle: A quantitative index of acute damage

Barry A. Siegel, W. King Engel, E. Carolyn Derrer

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

In rats with ischemic myopathy induced by aortic ligation and 5-hydroxytryptamine, there was good correlation of the skeletal muscle concentration of 99mTc-diphosphonate with the increase of plasma creatine phosphokinase and the decrease in muscle potassium. This radionuclide tracer method can be used to quantitate acute injury in individual muscles and provides a basis for clinical nuclear imaging in patients with a variety of disorders involving muscle fiber damage.

Original languageEnglish
Pages (from-to)1055-1058
Number of pages4
JournalNeurology
Volume25
Issue number11
StatePublished - Nov 1975
Externally publishedYes

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