⁶⁸Ga-DOTATATE and ¹⁸F-FDG PET/CT in a Rapidly Progressing Lymphoma

⁶⁸Ga-DOTATATE PET/CT targeting somatostatin receptors is commonly utilized in the imaging of neuroendocrine tumors. However, other malignancies such as lymphomas (both Hodgkin and non-Hodgkin) also have expression of somatostatin receptors, albeit to a lesser degree compared with the neuroendocrine tumors, and thus can be positive on a ⁶⁸Ga-DOTATATE PET/CT. We describe an atypical presentation of an aggressive large B-cell lymphoma mimicking a metastatic neuroendocrine tumor at initial presentation with high somatostatin receptor expression demonstrated on the ⁶⁸Ga-DOTATATE PET/CT and a rapidly progressing course on the subsequent ¹⁸F-FDG PET/CT.