68Ga DOTA-Exendin PET/CT for Detection of Insulinoma in a Patient with Persistent Hyperinsulinemic Hypoglycemia

Ashwin Singh Parihar; Shelvin Kumar Vadi; Rajender Kumar; Bhagwant Rai Mittal; Harmandeep Singh; Amanjit Bal; Rama Walia; Jaya Shukla; Saroj Kumar Sinha

doi:10.1097/RLU.0000000000002155

⁶⁸Ga DOTA-Exendin PET/CT for Detection of Insulinoma in a Patient with Persistent Hyperinsulinemic Hypoglycemia

Ashwin Singh Parihar, Shelvin Kumar Vadi, Rajender Kumar, Bhagwant Rai Mittal, Harmandeep Singh, Amanjit Bal, Rama Walia, Jaya Shukla, Saroj Kumar Sinha

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Insulinomas are the most common functioning pancreatic neuroendocrine tumors and the leading cause of persistent hypoglycemia with hyperinsulinemia in adults. Glucagon-like-peptide-1 (GLP) receptor analogs are the latest agents being used in the detection of insulinomas, with initial reports suggesting high sensitivity due to universal GLP1 receptor expression on these tumors. PET/CT imaging in this patient using ⁶⁸Ga DOTA-Exendin, a GLP receptor analog, proved useful for accurate localization of the culprit lesion, aiding in the definitive management of the patient.

Original language	English
Pages (from-to)	e285-e286
Journal	Clinical nuclear medicine
Volume	43
Issue number	8
DOIs	https://doi.org/10.1097/RLU.0000000000002155
State	Published - Aug 1 2018

Keywords

DOPA
Exendin
PET/CT
insulinoma
neuroendocrine tumors

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10.1097/RLU.0000000000002155

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title = "68Ga DOTA-Exendin PET/CT for Detection of Insulinoma in a Patient with Persistent Hyperinsulinemic Hypoglycemia",

abstract = "Insulinomas are the most common functioning pancreatic neuroendocrine tumors and the leading cause of persistent hypoglycemia with hyperinsulinemia in adults. Glucagon-like-peptide-1 (GLP) receptor analogs are the latest agents being used in the detection of insulinomas, with initial reports suggesting high sensitivity due to universal GLP1 receptor expression on these tumors. PET/CT imaging in this patient using 68Ga DOTA-Exendin, a GLP receptor analog, proved useful for accurate localization of the culprit lesion, aiding in the definitive management of the patient.",

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AU - Parihar, Ashwin Singh

AU - Vadi, Shelvin Kumar

AU - Kumar, Rajender

AU - Mittal, Bhagwant Rai

AU - Singh, Harmandeep

AU - Bal, Amanjit

AU - Walia, Rama

AU - Shukla, Jaya

AU - Sinha, Saroj Kumar

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Y1 - 2018/8/1

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AB - Insulinomas are the most common functioning pancreatic neuroendocrine tumors and the leading cause of persistent hypoglycemia with hyperinsulinemia in adults. Glucagon-like-peptide-1 (GLP) receptor analogs are the latest agents being used in the detection of insulinomas, with initial reports suggesting high sensitivity due to universal GLP1 receptor expression on these tumors. PET/CT imaging in this patient using 68Ga DOTA-Exendin, a GLP receptor analog, proved useful for accurate localization of the culprit lesion, aiding in the definitive management of the patient.

KW - DOPA

KW - Exendin

KW - PET/CT

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KW - neuroendocrine tumors

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⁶⁸Ga DOTA-Exendin PET/CT for Detection of Insulinoma in a Patient with Persistent Hyperinsulinemic Hypoglycemia

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