3He diffusion MRI of the lung

Mark S. Conradi; Dmitriy A. Yablonskiy; Jason C. Woods; David S. Gierada; Richard E. Jacob; Yulin V. Chang; Cliff K. Choong; Alex L. Sukstanskii; Tariq Tanoli; Stephen S. Lefrak; Joel D. Cooper

doi:10.1016/j.acra.2005.07.006

³He diffusion MRI of the lung

Mark S. Conradi, Dmitriy A. Yablonskiy, Jason C. Woods, David S. Gierada, Richard E. Jacob, Yulin V. Chang, Cliff K. Choong, Alex L. Sukstanskii, Tariq Tanoli, Stephen S. Lefrak, Joel D. Cooper

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33 Scopus citations

Abstract

Rationale and Objectives. MR imaging of the restricted diffusion of laser-polarized ³He gas provides unique insights into the changes in lung microstructure in emphysema. Results. We discuss measurements of ventilation (spin density), mean diffusivity, and the anisotropy of diffusion, which yields the mean acinar airway radius. In addition, the use of spatially modulated longitudinal magnetization allows diffusion to be measured over longer distances and times, with sensitivity to collateral ventilation paths. Early results are also presented for spin density and diffusivity maps made with a perfluorinated inert gas, C₃F₈. Methods. Techniques for purging and imaging excised lungs are discussed.

Original language	English
Pages (from-to)	1406-1413
Number of pages	8
Journal	Academic radiology
Volume	12
Issue number	11
DOIs	https://doi.org/10.1016/j.acra.2005.07.006
State	Published - Nov 2005

Keywords

Anisotropic diffusion
Diffusion MRI
Gas MRI
Helium-3
Lung

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10.1016/j.acra.2005.07.006

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@article{2dedfeac75fc45d1a64d6df84329469c,

title = "3He diffusion MRI of the lung",

abstract = "Rationale and Objectives. MR imaging of the restricted diffusion of laser-polarized 3He gas provides unique insights into the changes in lung microstructure in emphysema. Results. We discuss measurements of ventilation (spin density), mean diffusivity, and the anisotropy of diffusion, which yields the mean acinar airway radius. In addition, the use of spatially modulated longitudinal magnetization allows diffusion to be measured over longer distances and times, with sensitivity to collateral ventilation paths. Early results are also presented for spin density and diffusivity maps made with a perfluorinated inert gas, C3F8. Methods. Techniques for purging and imaging excised lungs are discussed.",

keywords = "Anisotropic diffusion, Diffusion MRI, Gas MRI, Helium-3, Lung",

author = "Conradi, {Mark S.} and Yablonskiy, {Dmitriy A.} and Woods, {Jason C.} and Gierada, {David S.} and Jacob, {Richard E.} and Chang, {Yulin V.} and Choong, {Cliff K.} and Sukstanskii, {Alex L.} and Tariq Tanoli and Lefrak, {Stephen S.} and Cooper, {Joel D.}",

note = "Funding Information: Supported by awards from the NIH (NHLBI R01HL70037 and R01HL72369). ",

year = "2005",

month = nov,

doi = "10.1016/j.acra.2005.07.006",

language = "English",

volume = "12",

pages = "1406--1413",

journal = "Academic radiology",

issn = "1076-6332",

number = "11",

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TY - JOUR

T1 - 3He diffusion MRI of the lung

AU - Conradi, Mark S.

AU - Yablonskiy, Dmitriy A.

AU - Woods, Jason C.

AU - Gierada, David S.

AU - Jacob, Richard E.

AU - Chang, Yulin V.

AU - Choong, Cliff K.

AU - Sukstanskii, Alex L.

AU - Tanoli, Tariq

AU - Lefrak, Stephen S.

AU - Cooper, Joel D.

N1 - Funding Information: Supported by awards from the NIH (NHLBI R01HL70037 and R01HL72369).

PY - 2005/11

Y1 - 2005/11

N2 - Rationale and Objectives. MR imaging of the restricted diffusion of laser-polarized 3He gas provides unique insights into the changes in lung microstructure in emphysema. Results. We discuss measurements of ventilation (spin density), mean diffusivity, and the anisotropy of diffusion, which yields the mean acinar airway radius. In addition, the use of spatially modulated longitudinal magnetization allows diffusion to be measured over longer distances and times, with sensitivity to collateral ventilation paths. Early results are also presented for spin density and diffusivity maps made with a perfluorinated inert gas, C3F8. Methods. Techniques for purging and imaging excised lungs are discussed.

AB - Rationale and Objectives. MR imaging of the restricted diffusion of laser-polarized 3He gas provides unique insights into the changes in lung microstructure in emphysema. Results. We discuss measurements of ventilation (spin density), mean diffusivity, and the anisotropy of diffusion, which yields the mean acinar airway radius. In addition, the use of spatially modulated longitudinal magnetization allows diffusion to be measured over longer distances and times, with sensitivity to collateral ventilation paths. Early results are also presented for spin density and diffusivity maps made with a perfluorinated inert gas, C3F8. Methods. Techniques for purging and imaging excised lungs are discussed.

KW - Anisotropic diffusion

KW - Diffusion MRI

KW - Gas MRI

KW - Helium-3

KW - Lung

UR - http://www.scopus.com/inward/record.url?scp=27244436288&partnerID=8YFLogxK

U2 - 10.1016/j.acra.2005.07.006

DO - 10.1016/j.acra.2005.07.006

M3 - Article

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AN - SCOPUS:27244436288

SN - 1076-6332

VL - 12

SP - 1406

EP - 1413

JO - Academic radiology

JF - Academic radiology

IS - 11

ER -

³He diffusion MRI of the lung

Abstract

Keywords

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