[18F]FDOPA PET and clinical features in Parkinsonism due to manganism

Brad A. Racette, Jo Ann Antenor, Lori McGee-Minnich, Stephen M. Moerlein, Tom O. Videen, Vikas Kotagal, Joel S. Perlmutter

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Manganese exposure reportedly causes a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of positron emission tomography with 6-[18F]fluorodopa ([18F]FDOPA PET) of a patient with parkinsonism occurring in the setting of elevated blood manganese. The patient developed parkinsonism associated with elevated serum manganese from hepatic dysfunction. [18F]FDOPA PET demonstrated relatively symmetric and severely reduced [18F]FDOPA levels in the posterior putamen compared to controls. The globus pallidum interna had increased signal on T1-weighted magnetic resonance imaging (MRI) images. We conclude that elevated manganese exposure may be associated with reduced striatal [18F]FDOPA uptake, and MRI may reveal selective abnormality within the internal segment of the pallidum. This case suggests that the clinical and pathophysiological features of manganese-associated parkinsonism may overlap with that of PD.

Original languageEnglish
Pages (from-to)492-496
Number of pages5
JournalMovement Disorders
Volume20
Issue number4
DOIs
StatePublished - Apr 1 2005

Keywords

  • Manganese
  • PET
  • Parkinson's disease

Fingerprint Dive into the research topics of '[<sup>18</sup>F]FDOPA PET and clinical features in Parkinsonism due to manganism'. Together they form a unique fingerprint.

  • Cite this