TY - JOUR
T1 - 18FDG PET-CT imaging detects arterial inflammation and early atherosclerosis in HIV-infected adults with cardiovascular disease risk factors
AU - Yarasheski, Kevin E.
AU - Laciny, Erin
AU - Overton, E. Turner
AU - Reeds, Dominic N.
AU - Harrod, Michael
AU - Baldwin, Steven
AU - Dávila-Román, Victor G.
N1 - Funding Information:
Kitty Krupp, RN provided nursing support in the PET suite. Joann L. Reagan, RN, RVT and Sharon L. Heuerman, RN provided support in the Cardiovascular Imaging and Clinical Research Core Laboratory. This publication was made possible by Grant # UL1 RR024992 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) and NIH Roadmap for Medical Research, and NIH grants R01 DK049393 (KEY) and P60 DK020579 (Diabetes Research Training Center). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH.
PY - 2012
Y1 - 2012
N2 - Background: Persistent vascular inflammation has been implicated as an important cause for a higher prevalence of cardiovascular disease (CVD) in HIV-infected adults. In several populations at high risk for CVD, vascular 18Fluorodeoxyglucose ( 18FDG) uptake quantified using 3D-positron emission-computed tomography (PET-CT) has been used as a molecular level biomarker for the presence of metabolically active proinflammatory macrophages in rupture-prone early atherosclerotic plaques. We hypothesized that 18FDG PET-CT imaging would detect arterial inflammation and early atherosclerosis in HIV-infected adults with modest CVD risk. Methods. We studied 9 HIV-infected participants with fully suppressed HIV viremia on antiretroviral therapy (8 men, median age 52yrs, median BMI 29kg/m 2, median CD4 count 655 cells/L, 33% current smokers) and 5 HIV-negative participants (4 men, median age 44yrs, median BMI 25kg/m 2, no current smokers). Mean Framingham Risk Scores were higher for HIV-infected persons (9% vs. 2%, p<0.01). 18FDG (370MBq) was administered intravenously. 3D-PET-CT images were obtained 3.5hrs later. 18FDG uptake into both carotid arteries and the aorta was compared between the two groups. Results: Right and left carotid 18FDG uptake was greater (P<0.03) in the HIV group (1.77 0.26, 1.33 0.09 target to background ratio (TBR)) than the control group (1.050.10, 1.030.05 TBR). 18FDG uptake in the aorta was greater in HIV (1.50 0.16 TBR) vs control group (1.240.05 TBR), but did not reach statistical significance (P=0.18). Conclusions: Carotid artery 18FDG PET-CT imaging detected differences in vascular inflammation and early atherosclerosis between HIV-infected adults with CVD risk factors and healthy HIV-seronegative controls. These findings confirm the utility of this molecular level imaging approach for detecting and quantifying glucose uptake into inflammatory macrophages present in metabolically active, rupture-prone atherosclerotic plaques in HIV infected adults; a population with increased CVD risk.
AB - Background: Persistent vascular inflammation has been implicated as an important cause for a higher prevalence of cardiovascular disease (CVD) in HIV-infected adults. In several populations at high risk for CVD, vascular 18Fluorodeoxyglucose ( 18FDG) uptake quantified using 3D-positron emission-computed tomography (PET-CT) has been used as a molecular level biomarker for the presence of metabolically active proinflammatory macrophages in rupture-prone early atherosclerotic plaques. We hypothesized that 18FDG PET-CT imaging would detect arterial inflammation and early atherosclerosis in HIV-infected adults with modest CVD risk. Methods. We studied 9 HIV-infected participants with fully suppressed HIV viremia on antiretroviral therapy (8 men, median age 52yrs, median BMI 29kg/m 2, median CD4 count 655 cells/L, 33% current smokers) and 5 HIV-negative participants (4 men, median age 44yrs, median BMI 25kg/m 2, no current smokers). Mean Framingham Risk Scores were higher for HIV-infected persons (9% vs. 2%, p<0.01). 18FDG (370MBq) was administered intravenously. 3D-PET-CT images were obtained 3.5hrs later. 18FDG uptake into both carotid arteries and the aorta was compared between the two groups. Results: Right and left carotid 18FDG uptake was greater (P<0.03) in the HIV group (1.77 0.26, 1.33 0.09 target to background ratio (TBR)) than the control group (1.050.10, 1.030.05 TBR). 18FDG uptake in the aorta was greater in HIV (1.50 0.16 TBR) vs control group (1.240.05 TBR), but did not reach statistical significance (P=0.18). Conclusions: Carotid artery 18FDG PET-CT imaging detected differences in vascular inflammation and early atherosclerosis between HIV-infected adults with CVD risk factors and healthy HIV-seronegative controls. These findings confirm the utility of this molecular level imaging approach for detecting and quantifying glucose uptake into inflammatory macrophages present in metabolically active, rupture-prone atherosclerotic plaques in HIV infected adults; a population with increased CVD risk.
KW - Atherogenesis
KW - Infectious disease
KW - Non-invasive imaging
KW - Pathophysiologic molecular-level biomarker
UR - http://www.scopus.com/inward/record.url?scp=84862514297&partnerID=8YFLogxK
U2 - 10.1186/1476-9255-9-26
DO - 10.1186/1476-9255-9-26
M3 - Article
C2 - 22726233
AN - SCOPUS:84862514297
SN - 1476-9255
VL - 9
JO - Journal of Inflammation (United Kingdom)
JF - Journal of Inflammation (United Kingdom)
M1 - 26
ER -