15O PET Imaging: Methods and Applications

Hongyu An; Manu S. Goyal; William J. Powers

doi:10.1007/978-3-030-82367-2_18

¹⁵O PET Imaging: Methods and Applications

Hongyu An, Manu S. Goyal, William J. Powers

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Oxygen metabolism plays a central role in maintaining normal neuronal functions and tissue integrity. The ability to evaluate cerebral blood flow, oxygen extraction fraction, and cerebral metabolic rate of oxygen is critical to understanding neurological diseases and brain functions. Several 15O positron emission tomography (PET) imaging methods were developed in the past decades to provide such measurements. Currently, 15O PET is considered the gold standard for in vivo regional oxygenation measurements. In this chapter, we summarize several PET methods and provide examples of their applications in studying normal brain physiology and functions, cerebrovascular diseases, and aging.

Original language	English
Title of host publication	Hybrid PET/MR Neuroimaging
Subtitle of host publication	A Comprehensive Approach
Publisher	Springer International Publishing
Pages	197-216
Number of pages	20
ISBN (Electronic)	9783030823672
ISBN (Print)	9783030823665
DOIs	https://doi.org/10.1007/978-3-030-82367-2_18
State	Published - Jan 1 2021

Keywords

O PET
Cerebral blood flow
Cerebral blood volume
Cerebral metabolic rate of oxygen
Oxygen extraction fraction

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10.1007/978-3-030-82367-2_18

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AU - An, Hongyu

AU - Goyal, Manu S.

AU - Powers, William J.

N1 - Publisher Copyright: © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Oxygen metabolism plays a central role in maintaining normal neuronal functions and tissue integrity. The ability to evaluate cerebral blood flow, oxygen extraction fraction, and cerebral metabolic rate of oxygen is critical to understanding neurological diseases and brain functions. Several 15O positron emission tomography (PET) imaging methods were developed in the past decades to provide such measurements. Currently, 15O PET is considered the gold standard for in vivo regional oxygenation measurements. In this chapter, we summarize several PET methods and provide examples of their applications in studying normal brain physiology and functions, cerebrovascular diseases, and aging.

AB - Oxygen metabolism plays a central role in maintaining normal neuronal functions and tissue integrity. The ability to evaluate cerebral blood flow, oxygen extraction fraction, and cerebral metabolic rate of oxygen is critical to understanding neurological diseases and brain functions. Several 15O positron emission tomography (PET) imaging methods were developed in the past decades to provide such measurements. Currently, 15O PET is considered the gold standard for in vivo regional oxygenation measurements. In this chapter, we summarize several PET methods and provide examples of their applications in studying normal brain physiology and functions, cerebrovascular diseases, and aging.

KW - O PET

KW - Cerebral blood flow

KW - Cerebral blood volume

KW - Cerebral metabolic rate of oxygen

KW - Oxygen extraction fraction

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SN - 9783030823665

SP - 197

EP - 216

BT - Hybrid PET/MR Neuroimaging

PB - Springer International Publishing

ER -

¹⁵O PET Imaging: Methods and Applications

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Keywords

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