13C and 15N resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue

Alexander M. Barclay; Dhruva D. Dhavale; Collin G. Borcik; Moses H. Milchberg; Paul T. Kotzbauer; Chad M. Rienstra

doi:10.1007/s12104-023-10156-0

¹³C and ¹⁵N resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue

Alexander M. Barclay
, Dhruva D. Dhavale
, Collin G. Borcik
, Moses H. Milchberg
, Paul T. Kotzbauer
, Chad M. Rienstra

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of ¹³C, ¹⁵N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.

Original language	English
Pages (from-to)	281-286
Number of pages	6
Journal	Biomolecular NMR Assignments
Volume	17
Issue number	2
DOIs	https://doi.org/10.1007/s12104-023-10156-0
State	Published - Dec 2023

Keywords

Fibrils
Lewy Body Dementia
Parkinson Disease
Polymorphism
αSynuclein

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10.1007/s12104-023-10156-0

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title = "13C and 15N resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue",

abstract = "Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of 13C, 15N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.",

keywords = "Fibrils, Lewy Body Dementia, Parkinson Disease, Polymorphism, αSynuclein",

author = "Barclay, \{Alexander M.\} and Dhavale, \{Dhruva D.\} and Borcik, \{Collin G.\} and Milchberg, \{Moses H.\} and Kotzbauer, \{Paul T.\} and Rienstra, \{Chad M.\}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature B.V.",

year = "2023",

month = dec,

doi = "10.1007/s12104-023-10156-0",

language = "English",

volume = "17",

pages = "281--286",

journal = "Biomolecular NMR Assignments",

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T1 - 13C and 15N resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue

AU - Barclay, Alexander M.

AU - Dhavale, Dhruva D.

AU - Borcik, Collin G.

AU - Milchberg, Moses H.

AU - Kotzbauer, Paul T.

AU - Rienstra, Chad M.

PY - 2023/12

Y1 - 2023/12

N2 - Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of 13C, 15N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.

AB - Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of 13C, 15N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.

KW - Fibrils

KW - Lewy Body Dementia

KW - Parkinson Disease

KW - Polymorphism

KW - αSynuclein

UR - https://www.scopus.com/pages/publications/85175559759

U2 - 10.1007/s12104-023-10156-0

DO - 10.1007/s12104-023-10156-0

M3 - Article

C2 - 37919529

AN - SCOPUS:85175559759

SN - 1874-2718

VL - 17

SP - 281

EP - 286

JO - Biomolecular NMR Assignments

JF - Biomolecular NMR Assignments

IS - 2

ER -

¹³C and ¹⁵N resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue

Abstract

Keywords

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