[11C]ER176 images brain inflammation across TSPO genotypes and colocalizes with tau

Aisling M. Chaney; Brian A. Gordon

doi:10.1016/j.tins.2025.03.005

[¹¹C]ER176 images brain inflammation across TSPO genotypes and colocalizes with tau

Research output: Contribution to journal › Short survey › peer-review

Abstract

Accurately measuring brain inflammation in Alzheimer's disease (AD) is crucial due to the role of inflammatory processes in neurodegeneration. In a recent study, Appleton, Finn, et al. used [¹¹C]ER176, a novel translocator protein 18 kDa (TSPO)-positron emission tomography (PET) tracer overcoming genotype-related binding issues, to show increased inflammation in early-onset AD, with patterns aligning more closely with tau pathology than amyloid deposition or atrophy.

Original language	English
Pages (from-to)	315-316
Number of pages	2
Journal	Trends in Neurosciences
Volume	48
Issue number	5
DOIs	https://doi.org/10.1016/j.tins.2025.03.005
State	Published - May 2025

Keywords

TSPO-PET
molecular imaging
neurodegeneration
neuroimaging
neuroinflammation

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10.1016/j.tins.2025.03.005

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title = "[11C]ER176 images brain inflammation across TSPO genotypes and colocalizes with tau",

abstract = "Accurately measuring brain inflammation in Alzheimer's disease (AD) is crucial due to the role of inflammatory processes in neurodegeneration. In a recent study, Appleton, Finn, et al. used [11C]ER176, a novel translocator protein 18 kDa (TSPO)-positron emission tomography (PET) tracer overcoming genotype-related binding issues, to show increased inflammation in early-onset AD, with patterns aligning more closely with tau pathology than amyloid deposition or atrophy.",

keywords = "TSPO-PET, molecular imaging, neurodegeneration, neuroimaging, neuroinflammation",

author = "Chaney, \{Aisling M.\} and Gordon, \{Brian A.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = may,

doi = "10.1016/j.tins.2025.03.005",

language = "English",

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journal = "Trends in Neurosciences",

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AU - Chaney, Aisling M.

AU - Gordon, Brian A.

PY - 2025/5

Y1 - 2025/5

N2 - Accurately measuring brain inflammation in Alzheimer's disease (AD) is crucial due to the role of inflammatory processes in neurodegeneration. In a recent study, Appleton, Finn, et al. used [11C]ER176, a novel translocator protein 18 kDa (TSPO)-positron emission tomography (PET) tracer overcoming genotype-related binding issues, to show increased inflammation in early-onset AD, with patterns aligning more closely with tau pathology than amyloid deposition or atrophy.

AB - Accurately measuring brain inflammation in Alzheimer's disease (AD) is crucial due to the role of inflammatory processes in neurodegeneration. In a recent study, Appleton, Finn, et al. used [11C]ER176, a novel translocator protein 18 kDa (TSPO)-positron emission tomography (PET) tracer overcoming genotype-related binding issues, to show increased inflammation in early-onset AD, with patterns aligning more closely with tau pathology than amyloid deposition or atrophy.

KW - TSPO-PET

KW - molecular imaging

KW - neurodegeneration

KW - neuroimaging

KW - neuroinflammation

UR - https://www.scopus.com/pages/publications/105001857778

U2 - 10.1016/j.tins.2025.03.005

DO - 10.1016/j.tins.2025.03.005

M3 - Short survey

C2 - 40187909

AN - SCOPUS:105001857778

SN - 0166-2236

VL - 48

SP - 315

EP - 316

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 5

ER -

[¹¹C]ER176 images brain inflammation across TSPO genotypes and colocalizes with tau

Abstract

Keywords

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