Summary of the UPICT protocol for 18F-FDG PET/CT imaging in oncology clinical trials

Michael M. Graham, Richard L. Wahl, John M. Hoffman, Jeffrey T. Yap, John J. Sunderland, Ronald Boellaard, Eric S. Perlman, Paul E. Kinahan, Paul E. Christian, Otto S. Hoekstra, Gary S. Dorfman

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Abstract

The Uniform Protocols for Imaging in Clinical Trials (UPICT) 18F-FDG PET/CT protocol is intended to guide the performance of whole-body FDG PET/CT studies within the context of single-andmultiple-center clinical trials of oncologic therapies by providing acceptable (minimum), target, and ideal standards for all phases of imaging. The aim is to minimize variability in intra-and intersubject, intra-and interplatform, interexamination, and interinstitutional primary or derived data. The goal of this condensed version of the much larger document is to make readers aware of the general content and subject area. The document has several main subjects: context of the imaging protocol within the clinical trial; site selection, qualification, and training; subject scheduling; subject preparation; imaging-related substance preparation and administration; imaging procedure; image postprocessing; image analysis; image interpretation; archiving and distribution of data; quality control; and imaging-associated risks and risk management.

Original languageEnglish
Pages (from-to)955-961
Number of pages7
JournalJournal of Nuclear Medicine
Volume56
Issue number6
DOIs
StatePublished - Jun 1 2015

Keywords

  • Fluorodeoxyglucose
  • Guideline
  • PET CT
  • Protocol

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    Graham, M. M., Wahl, R. L., Hoffman, J. M., Yap, J. T., Sunderland, J. J., Boellaard, R., Perlman, E. S., Kinahan, P. E., Christian, P. E., Hoekstra, O. S., & Dorfman, G. S. (2015). Summary of the UPICT protocol for 18F-FDG PET/CT imaging in oncology clinical trials. Journal of Nuclear Medicine, 56(6), 955-961. https://doi.org/10.2967/jnumed.115.158402