TY - JOUR
T1 - Summary of the first inaugural joint meeting of the International Consortium for scoliosis genetics and the International Consortium for vertebral anomalies and scoliosis, March 16–18, 2017, Dallas, Texas
AU - Giampietro, Philip F.
AU - Pourquie, Olivier
AU - Raggio, Cathy
AU - Ikegawa, Shiro
AU - Turnpenny, Peter D.
AU - Gray, Ryan
AU - Dunwoodie, Sally L.
AU - Gurnett, Christina A.
AU - Alman, Benjamin
AU - Cheung, Kenneth
AU - Kusumi, Kenro
AU - Hadley-Miller, Nancy
AU - Wise, Carol A.
N1 - Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2018/1
Y1 - 2018/1
N2 - Scoliosis represents the most common musculoskeletal disorder in children and affects approximately 3% of the world population. Scoliosis is separated into two major phenotypic classifications: congenital and idiopathic. Idiopathic scoliosis is defined as a curvature of the spine of 10° or greater visualized on plane radiograph and does not have associated vertebral malformations (VM). “Congenital” scoliosis (CS) due to malformations in vertebrae is frequently associated with other birth defects. Recently, significant advances have been made in understanding the genetic basis of both conditions. There is evidence that both conditions are etiologically related. A 2-day conference entitled “Genomic Approaches to Understanding and Treating Scoliosis” was held at Scottish Rite Hospital for Children in Dallas, Texas, to synergize research in this field. This first combined, multidisciplinary conference featured international scoliosis researchers in basic and clinical sciences. A major outcome of the conference advancing scoliosis research was the proposal and subsequent vote in favor of merging the International Consortium for Vertebral Anomalies and Scoliosis (ICVAS) and International Consortium for Scoliosis Genetics (ICSG) into a single entity called International Consortium for Spinal Genetics, Development, and Disease (ICSGDD). The ICSGDD is proposed to meet annually as a forum to synergize multidisciplinary spine deformity research.
AB - Scoliosis represents the most common musculoskeletal disorder in children and affects approximately 3% of the world population. Scoliosis is separated into two major phenotypic classifications: congenital and idiopathic. Idiopathic scoliosis is defined as a curvature of the spine of 10° or greater visualized on plane radiograph and does not have associated vertebral malformations (VM). “Congenital” scoliosis (CS) due to malformations in vertebrae is frequently associated with other birth defects. Recently, significant advances have been made in understanding the genetic basis of both conditions. There is evidence that both conditions are etiologically related. A 2-day conference entitled “Genomic Approaches to Understanding and Treating Scoliosis” was held at Scottish Rite Hospital for Children in Dallas, Texas, to synergize research in this field. This first combined, multidisciplinary conference featured international scoliosis researchers in basic and clinical sciences. A major outcome of the conference advancing scoliosis research was the proposal and subsequent vote in favor of merging the International Consortium for Vertebral Anomalies and Scoliosis (ICVAS) and International Consortium for Scoliosis Genetics (ICSG) into a single entity called International Consortium for Spinal Genetics, Development, and Disease (ICSGDD). The ICSGDD is proposed to meet annually as a forum to synergize multidisciplinary spine deformity research.
KW - GWAS
KW - congenital scoliosis
KW - idiopathic scoliosis
KW - natural history
KW - phenotypic classification
KW - spine deformity
UR - http://www.scopus.com/inward/record.url?scp=85034586128&partnerID=8YFLogxK
U2 - 10.1002/ajmg.a.38550
DO - 10.1002/ajmg.a.38550
M3 - Article
C2 - 29159998
AN - SCOPUS:85034586128
SN - 1552-4825
VL - 176
SP - 253
EP - 256
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
IS - 1
ER -