TY - JOUR
T1 - Sulfonylurea Receptor 1 Subunits of ATP-Sensitive Potassium Channels and Myocardial Ischemia/Reperfusion Injury
AU - Lefer, David J.
AU - Nichols, Colin G.
AU - Coetzee, William A.
N1 - Funding Information:
D.J.L. is supported by a grant from the National Institutes of Health 7R01 HL060849-09. C.G.N. is supported by a grant from the National Institutes of Health 1R01HL095010-01, and W.A.C. is supported by a grant from the National Institutes of Health 5R01HL085820-02, and partial support is provided by the 7th Masonic District.
PY - 2009/2
Y1 - 2009/2
N2 - KATP channels are generally cardioprotective under conditions of metabolic impairment, consisting of pore-forming (Kir6.1 and/or Kir6.2) and sulphonylurea-binding, modulatory subunits [sulfonylurea receptor (SUR) 1, 2A, or 2B]. Cardiovascular KATP channels are generally thought to consist of Kir6.2/SUR2A subunits (in the case of heart muscle) or Kir6.1/SUR2B subunits (smooth muscle), whereas SUR1-containing channels have well-documented roles in pancreatic insulin release. Recent data, however, demonstrated the presence of SUR1 subunits in mouse cardiac tissue (particularly in atria) and a surprising protection from myocardial ischemia/reperfusion in SUR1-null mice. Here, we review some of the extra-pancreatic roles assigned to SUR1 subunits and consider whether these might be involved in the sequelae of ischemia/reperfusion.
AB - KATP channels are generally cardioprotective under conditions of metabolic impairment, consisting of pore-forming (Kir6.1 and/or Kir6.2) and sulphonylurea-binding, modulatory subunits [sulfonylurea receptor (SUR) 1, 2A, or 2B]. Cardiovascular KATP channels are generally thought to consist of Kir6.2/SUR2A subunits (in the case of heart muscle) or Kir6.1/SUR2B subunits (smooth muscle), whereas SUR1-containing channels have well-documented roles in pancreatic insulin release. Recent data, however, demonstrated the presence of SUR1 subunits in mouse cardiac tissue (particularly in atria) and a surprising protection from myocardial ischemia/reperfusion in SUR1-null mice. Here, we review some of the extra-pancreatic roles assigned to SUR1 subunits and consider whether these might be involved in the sequelae of ischemia/reperfusion.
UR - http://www.scopus.com/inward/record.url?scp=67649450486&partnerID=8YFLogxK
U2 - 10.1016/j.tcm.2009.04.008
DO - 10.1016/j.tcm.2009.04.008
M3 - Review article
C2 - 19577714
AN - SCOPUS:67649450486
SN - 1050-1738
VL - 19
SP - 61
EP - 67
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 2
ER -