Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists

Andrew G. Cole; Axel Metzger; Marc Raleigh Brescia; Lan Ying Qin; Kenneth C. Appell; Christopher T. Brain; Allan Hallett; Pam Ganju; Alastair A. Denholm; James R. Wareing; Timothy J. Ritchie; Gillian M. Drake; Stuart J. Bevan; Aisling MacGloinn; Andrew McBryde; Viral Patel; Paul J. Oakley; Ximena Nunez; Hubert Gstach; Peter Schneider; John J. Baldwin; Roland E. Dolle; Edward McDonald; Ian Henderson

doi:10.1016/j.bmcl.2008.11.005

Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists

Andrew G. Cole, Axel Metzger, Marc Raleigh Brescia, Lan Ying Qin, Kenneth C. Appell, Christopher T. Brain, Allan Hallett, Pam Ganju, Alastair A. Denholm, James R. Wareing, Timothy J. Ritchie, Gillian M. Drake, Stuart J. Bevan, Aisling MacGloinn, Andrew McBryde, Viral Patel, Paul J. Oakley, Ximena Nunez, Hubert Gstach, Peter SchneiderJohn J. Baldwin, Roland E. Dolle, Edward McDonald, Ian Henderson

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The synthesis and identification of sulfonamido-aryl ethers as potent bradykinin B1 receptor antagonists from a ∼60,000 member encoded combinatorial library are reported. Two distinct series of compounds exhibiting different structure-activity relationships were identified in a bradykinin B1 whole-cell receptor-binding assay. Specific examples exhibit K_i values of ∼10 nM.

Original language	English
Pages (from-to)	119-122
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2008.11.005
State	Published - Jan 1 2009

Keywords

Bradykinin
Combinatorial chemistry
ECLiPS
Sulfonamide

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Cole, A. G., Metzger, A., Brescia, M. R., Qin, L. Y., Appell, K. C., Brain, C. T., Hallett, A., Ganju, P., Denholm, A. A., Wareing, J. R., Ritchie, T. J., Drake, G. M., Bevan, S. J., MacGloinn, A., McBryde, A., Patel, V., Oakley, P. J., Nunez, X., Gstach, H., ... Henderson, I. (2009). Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 19(1), 119-122. https://doi.org/10.1016/j.bmcl.2008.11.005

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abstract = "The synthesis and identification of sulfonamido-aryl ethers as potent bradykinin B1 receptor antagonists from a ∼60,000 member encoded combinatorial library are reported. Two distinct series of compounds exhibiting different structure-activity relationships were identified in a bradykinin B1 whole-cell receptor-binding assay. Specific examples exhibit Ki values of ∼10 nM.",

keywords = "Bradykinin, Combinatorial chemistry, ECLiPS, Sulfonamide",

author = "Cole, {Andrew G.} and Axel Metzger and Brescia, {Marc Raleigh} and Qin, {Lan Ying} and Appell, {Kenneth C.} and Brain, {Christopher T.} and Allan Hallett and Pam Ganju and Denholm, {Alastair A.} and Wareing, {James R.} and Ritchie, {Timothy J.} and Drake, {Gillian M.} and Bevan, {Stuart J.} and Aisling MacGloinn and Andrew McBryde and Viral Patel and Oakley, {Paul J.} and Ximena Nunez and Hubert Gstach and Peter Schneider and Baldwin, {John J.} and Dolle, {Roland E.} and Edward McDonald and Ian Henderson",

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doi = "10.1016/j.bmcl.2008.11.005",

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Cole, AG, Metzger, A, Brescia, MR, Qin, LY, Appell, KC, Brain, CT, Hallett, A, Ganju, P, Denholm, AA, Wareing, JR, Ritchie, TJ, Drake, GM, Bevan, SJ, MacGloinn, A, McBryde, A, Patel, V, Oakley, PJ, Nunez, X, Gstach, H, Schneider, P, Baldwin, JJ, Dolle, RE, McDonald, E & Henderson, I 2009, 'Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 1, pp. 119-122. https://doi.org/10.1016/j.bmcl.2008.11.005

TY - JOUR

T1 - Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists

AU - Cole, Andrew G.

AU - Metzger, Axel

AU - Brescia, Marc Raleigh

AU - Qin, Lan Ying

AU - Appell, Kenneth C.

AU - Brain, Christopher T.

AU - Hallett, Allan

AU - Ganju, Pam

AU - Denholm, Alastair A.

AU - Wareing, James R.

AU - Ritchie, Timothy J.

AU - Drake, Gillian M.

AU - Bevan, Stuart J.

AU - MacGloinn, Aisling

AU - McBryde, Andrew

AU - Patel, Viral

AU - Oakley, Paul J.

AU - Nunez, Ximena

AU - Gstach, Hubert

AU - Schneider, Peter

AU - Baldwin, John J.

AU - Dolle, Roland E.

AU - McDonald, Edward

AU - Henderson, Ian

PY - 2009/1/1

Y1 - 2009/1/1

N2 - The synthesis and identification of sulfonamido-aryl ethers as potent bradykinin B1 receptor antagonists from a ∼60,000 member encoded combinatorial library are reported. Two distinct series of compounds exhibiting different structure-activity relationships were identified in a bradykinin B1 whole-cell receptor-binding assay. Specific examples exhibit Ki values of ∼10 nM.

AB - The synthesis and identification of sulfonamido-aryl ethers as potent bradykinin B1 receptor antagonists from a ∼60,000 member encoded combinatorial library are reported. Two distinct series of compounds exhibiting different structure-activity relationships were identified in a bradykinin B1 whole-cell receptor-binding assay. Specific examples exhibit Ki values of ∼10 nM.

KW - Bradykinin

KW - Combinatorial chemistry

KW - ECLiPS

KW - Sulfonamide

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DO - 10.1016/j.bmcl.2008.11.005

M3 - Article

C2 - 19014884

AN - SCOPUS:57749090167

SN - 0960-894X

VL - 19

SP - 119

EP - 122

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists

Abstract

Keywords

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