Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils

W. F. Stenson, E. Lobos

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


Neutrophils metabolize arachidonic acid through the lipoxygenase pathway to 5-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) and 5,12-dihydroxy-6,8,10,14-eicosatraenoic acid (5,12 di-HETE). 5-HETE and 5,12 diHETE are potent chemotactic agents and are thought to have important roles in the inflammatory response. In this study we demonstrate that sulfasalazine, at concentrations found in the stool of patients being treated for ulcerative colitis, blocks the synthesis of both 5-HETE and 5,12 diHETE by human neutrophils. A sulfasalazine metabolite, 5-aminosalicylate, also blocks the synthesis of 5,12 diHETE.

Original languageEnglish
Pages (from-to)494-497
Number of pages4
JournalJournal of Clinical Investigation
Issue number2
StatePublished - 1982


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