TY - JOUR
T1 - Suggestive linkage of chromosome 10p to schizophrenia is not due to transmission ratio distortion
AU - Faraone, Stephen V.
AU - Meyer, Joanne
AU - Matise, Tara
AU - Svrakic, Dragun
AU - Pepple, John
AU - Malaspina, Dolores
AU - Suarez, Brian
AU - Hampe, Carol
AU - Chan, Gayan
AU - Aelony, Avram
AU - Friedman, Jill Harkavy
AU - Kaufmann, Charles
AU - Cloninger, C. Robert
AU - Tsuang, Ming T.
PY - 1999/12/15
Y1 - 1999/12/15
N2 - The genome scan of the European-American schizophrenia families from the Human Genetics Initiative of the National Institute of Mental Health (NIMH) reported a suggestive linkage to chromosome 10p. Subsequently, Paterson and Petronis [1999] reported evidence for transmission ratio distortion on 10p to females. They suggested that transmission ratio distortion to females might have created spurious evidence for linkage to 10p. To address this issue, we reanalyzed our 10p data using only male-male affected sibling pairs. The two chromosome 10p markers that gave the most evidence for linkage in our prior report continued to show evidence for linkage: D10S1423 (NPL Z = 3.0, P = 0.001) and its neighbor D10S582 (NPL Z = 2.9, P = 0.002). These data suggest that our prior report of suggestive linkage of schizophrenia to markers on 10p cannot be attributed to the transmission ratio distortion to females reported by Paterson and Petronis.
AB - The genome scan of the European-American schizophrenia families from the Human Genetics Initiative of the National Institute of Mental Health (NIMH) reported a suggestive linkage to chromosome 10p. Subsequently, Paterson and Petronis [1999] reported evidence for transmission ratio distortion on 10p to females. They suggested that transmission ratio distortion to females might have created spurious evidence for linkage to 10p. To address this issue, we reanalyzed our 10p data using only male-male affected sibling pairs. The two chromosome 10p markers that gave the most evidence for linkage in our prior report continued to show evidence for linkage: D10S1423 (NPL Z = 3.0, P = 0.001) and its neighbor D10S582 (NPL Z = 2.9, P = 0.002). These data suggest that our prior report of suggestive linkage of schizophrenia to markers on 10p cannot be attributed to the transmission ratio distortion to females reported by Paterson and Petronis.
KW - Chromosome 10
KW - Linkage
KW - Schizophrenia
KW - Transmission ratio distortion
UR - http://www.scopus.com/inward/record.url?scp=0033573316&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-8628(19991215)88:6<607::AID-AJMG6>3.0.CO;2-Q
DO - 10.1002/(SICI)1096-8628(19991215)88:6<607::AID-AJMG6>3.0.CO;2-Q
M3 - Article
C2 - 10581477
AN - SCOPUS:0033573316
SN - 1552-4841
VL - 88
SP - 607
EP - 608
JO - American Journal of Medical Genetics - Neuropsychiatric Genetics
JF - American Journal of Medical Genetics - Neuropsychiatric Genetics
IS - 6
ER -