TY - JOUR
T1 - Sugar and sugar-sweetened beverages in relation to premature aging in adult survivors of childhood cancer
AU - Lan, Tuo
AU - Wang, Mei
AU - Williams, Anna Lynn M.
AU - Ehrhardt, Matthew J.
AU - Jiang, Shu
AU - Huang, I. Chan
AU - Lanctot, Jennifer Q.
AU - Krull, Kevin R.
AU - Armstrong, Gregory T.
AU - Hudson, Melissa M.
AU - Colditz, Graham A.
AU - Robison, Leslie L.
AU - Ness, Kirsten K.
AU - Park, Yikyung
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature Limited 2024.
PY - 2024/10/19
Y1 - 2024/10/19
N2 - Background: Premature aging is a significant concern in adult survivors of childhood cancer as they develop aging-related conditions at a younger age than their peers with no history of childhood cancer. Although modifiable lifestyle factors, such as diet, are postulated to affect aging process, supporting evidence is sparse. Methods: We examined if the consumption of sugar and sugar-sweetened beverages was related to premature aging in 3322 adult survivors of childhood cancer in the St. Jude Lifetime Cohort. Premature aging was assessed using the Deficit Accumulation Index (DAI) that was a ratio of the number of age-related chronic health conditions each survivor had out of 44 conditions total. Multinomial logistic regressions adjusting for confounders were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: There were 46% of childhood cancer survivors consumed SSBs once or more times per day. High intake of sugar, especially sugars added to foods during preparation or processing, and habitual consumption of sugar-sweetened beverage were associated with an increased risk of premature aging. Discussion: Our findings support a need to include strategies to reduce sugar and sugar-sweetened beverages consumption in lifestyle interventions to promote healthy aging in adult survivors of childhood cancer.
AB - Background: Premature aging is a significant concern in adult survivors of childhood cancer as they develop aging-related conditions at a younger age than their peers with no history of childhood cancer. Although modifiable lifestyle factors, such as diet, are postulated to affect aging process, supporting evidence is sparse. Methods: We examined if the consumption of sugar and sugar-sweetened beverages was related to premature aging in 3322 adult survivors of childhood cancer in the St. Jude Lifetime Cohort. Premature aging was assessed using the Deficit Accumulation Index (DAI) that was a ratio of the number of age-related chronic health conditions each survivor had out of 44 conditions total. Multinomial logistic regressions adjusting for confounders were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: There were 46% of childhood cancer survivors consumed SSBs once or more times per day. High intake of sugar, especially sugars added to foods during preparation or processing, and habitual consumption of sugar-sweetened beverage were associated with an increased risk of premature aging. Discussion: Our findings support a need to include strategies to reduce sugar and sugar-sweetened beverages consumption in lifestyle interventions to promote healthy aging in adult survivors of childhood cancer.
UR - http://www.scopus.com/inward/record.url?scp=85200964254&partnerID=8YFLogxK
U2 - 10.1038/s41416-024-02815-3
DO - 10.1038/s41416-024-02815-3
M3 - Article
C2 - 39117799
AN - SCOPUS:85200964254
SN - 0007-0920
VL - 131
SP - 1169
EP - 1177
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 7
ER -