Successful treatment of metastatic cerebral recurrence of pleuropulmonary blastoma

Yoshiko Nakano, Sandra Pisa Gatell, Kris Ann P. Schultz, Thais Murciano Carrillo, Hiroyuki Fujisaki, Keiko Okada, Masaki Horiike, Tetsuro Nakamura, Yusuke Watanabe, Yasuhiro Matsusaka, Hiroaki Sakamoto, Hiroko Fukushima, Takeshi Inoue, Gretchen M. Williams, D. Ashley Hill, Junichi Hara

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Pleuropulmonary blastoma (PPB) is a rare pediatric tumor. The central nervous system (CNS) is the most common site of extrathoracic metastasis. The prognosis of PPB patients with CNS metastases is dismal: most patients die within one year after recurrence. Here, we describe two patients diagnosed with PPB who developed intracranial recurrences shortly after the end of their initial treatment and were successfully treated by gross total resection, radiotherapy, and chemotherapy. Both patients are in complete remission four and three years after recurrence. Although an optimal regimen remains to be determined, these cases demonstrate that PPB with CNS metastases is potentially curable.

Original languageEnglish
Article numbere27628
JournalPediatric Blood and Cancer
Volume66
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • CNS relapse
  • metronomic therapy
  • pleuropulmonary blastoma
  • treatment

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