Successful treatment of inflammatory myofibroblastic tumor with malignant transformation by surgical resection and chemotherapy

Megan K. Dishop, Brad W. Warner, Louis P. Dehner, Vesna M. Kriss, Martha F. Greenwood, John D. Geil, Jeffrey A. Moscow

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Inflammatory myofibroblastic tumor (IMT) is a tumor composed of myofibroblasts and a mixed inflammatory infiltrate that rarely undergoes malignant transformation. The authors present the case of a 7-year-old boy with an abdominal mass diagnosed as IMT with malignant transformation. The tumor recurred twice after attempts at resection and was initially treated with vincristine and etoposide. After a third recurrence and incomplete resection, he was treated with cisplatin, Adriamycin, and methotrexate. He is disease-free after 2 years, representing successful combined surgery and chemotherapy in the treatment of malignant IMT. The use of chemotherapy for aggressive myofibroblastic tumors is reviewed.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalJournal of Pediatric Hematology/Oncology
Volume25
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Abdominal mass
  • Chemotherapy
  • Children
  • Inflammatory myofibroblastic tumor
  • Inflammatory pseudotumor
  • Malignant transformation

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