Successful treatment of cerebral toxoplasmosis in a marrow transplant recipient: Contribution of a PCR test in diagnosis and early detection

H. Khoury, D. Adkins, R. Brown, L. Goodnough, M. Gokden, T. Roberts, G. Storch, J. DiPersio

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

We report successful treatment of cerebral toxoplasmosis in an unrelated donor marrow transplant recipient. The clinical diagnosis was confirmed by polymerase chain reaction (PCR) amplification for T. gondii-DNA performed both on cerebrospinal fluid and blood leukocytes. Retrospective testing of stored blood samples demonstrated positive leukocyte PCR signal detected up to 52 days prior to onset of clinical symptoms. This case highlights the value of PCR in the diagnosis and early detection of cerebral toxoplasmosis.

Original languageEnglish
Pages (from-to)409-411
Number of pages3
JournalBone Marrow Transplantation
Volume23
Issue number4
DOIs
StatePublished - Jan 1 1999

Keywords

  • Cerebral
  • Marrow transplantation
  • PCR
  • Toxoplasmosis

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