Substantial genetic overlap between schizotypy and neuroticism: A twin study

Christine MacAr, Timothy C. Bates, Andrew C. Heath, Nicholas G. Martin, Ulrich Ettinger

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Schizotypy is phenotypically associated with neuroticism. To reveal the origin of this association, we assessed 3,349 (1,449 monozygotic, 1,105 dizygotic [DZ] same-sex and 795 DZ opposite-sex) twins on a 12-item version of Chapman's Psychosis-Proneness Scales and the short form of the Eysenck Personality Questionnaire-Revised as measures of schizotypy and neuroticism. A substantial proportion (0.51 with 95 % CI from 0.38 to 0.64) of the phenotypic correlation of 0.37 between neuroticism and the perceptual and ideational components of schizotypy was accounted for by shared genetic influences on these two traits. Moreover, a Cholesky decomposition including anhedonia, hypomania and impulsivity fully accounted for the heritable variance in perceptual and ideational components of schizotypy. These findings suggest a shared genetic etiology between neuroticism and perceptual and ideational components of schizotypy and affect future investigations on the etiology of these phenotypically overlapping traits and affective and psychotic disorders.

Original languageEnglish
Pages (from-to)732-742
Number of pages11
JournalBehavior genetics
Volume42
Issue number5
DOIs
StatePublished - Sep 2012

Keywords

  • Behavior genetics
  • Magical ideation
  • Neuroticism
  • Perceptual aberr ation
  • Phenotypic correlation
  • Schizotypy

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