Substance P neurons project from the ventral medulla to the intermediolateral cell column and ventral horn in the rat

Cinda J. Helke, Jeffrey J. Neil, V. John Massari, Arthur D. Loewy

Research output: Contribution to journalArticle

162 Scopus citations

Abstract

The descending substance P projections from the ventral medulla were studied in the rat. Electrolytic lesions which included the nucleus interfascicularis hypoglossi decrease the substance P-like immunoreactivity (SP-I) in both the intermediolateral cell column and the ventral horn of the spinal cord. Lesions of other ventral medullary areas and midbrain hemisections did not change spinal cord SP-I levels. Intracerebroventricular administration of the serotonin neurotoxin, 5,7-dihydroxytryptamine, reduced the SP-I content of the ventral horn but not of the intermediolateral cell colum.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalBrain Research
Volume243
Issue number1
DOIs
StatePublished - Jul 8 1982

Keywords

  • intermediolateral cell column
  • raphe nuclei
  • substance P
  • ventral horn of the spinal cord
  • ventral medulla

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