Submandibular gland transfer for the prevention of radiation-induced xerostomia in oropharyngeal cancer: Dosimetric impact in the intensity modulated radiotherapy era

Tugce Kutuk; Nicole C. McAllister; Amy E. Rzepczynski; Andre Williams; Geoffrey Young; Meghan B. Crawley; Guilherme Rabinowits; Adeel Kaiser; Jessika A. Contreras; Noah S. Kalman

doi:10.1002/hed.27021

Submandibular gland transfer for the prevention of radiation-induced xerostomia in oropharyngeal cancer: Dosimetric impact in the intensity modulated radiotherapy era

Tugce Kutuk
, Nicole C. McAllister
, Amy E. Rzepczynski
, Andre Williams
, Geoffrey Young
, Meghan B. Crawley
, Guilherme Rabinowits
, Adeel Kaiser
, Jessika A. Contreras
, Noah S. Kalman

Division of Clinical Research

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Submandibular gland (SMG) transfer decreased radiation-associated xerostomia in the 2/3-dimensional radiotherapy era. We evaluated the dosimetric implications of SMG transfer on modern intensity modulated radiotherapy (IMRT) plans. Methods: Eighteen oropharynx cancer patients underwent SMG transfer followed by IMRT; reoptimized plans using the baseline SMG location were generated. Mean salivary gland, oral cavity, and larynx doses were compared between clinical plans and reoptimized plans. Results: No statistically significant difference in mean SMG dose (27.53 Gy vs. 29.61 Gy) or total salivary gland dose (26.12 Gy vs. 26.41 Gy) was observed with or without SMG transfer (all p > 0.05). Mean oral cavity and larynx doses were not statistically different. Neither tumor site, target volume crossing midline, stage, nor salivary gland volumes were associated with mean doses. Conclusions: Salivary gland doses were similar with or without SMG transfer. IMRT likely decreases the benefit of SMG transfer on the risk of radiation-associated xerostomia.

Original language	English
Pages (from-to)	1213-1222
Number of pages	10
Journal	Head and Neck
Volume	44
Issue number	5
DOIs	https://doi.org/10.1002/hed.27021
State	Published - May 2022

Keywords

IMRT
radiotherapy
submandibular gland
transfer surgery
xerostomia

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10.1002/hed.27021

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Kutuk, T., McAllister, N. C., Rzepczynski, A. E., Williams, A., Young, G., Crawley, M. B., Rabinowits, G., Kaiser, A., Contreras, J. A., & Kalman, N. S. (2022). Submandibular gland transfer for the prevention of radiation-induced xerostomia in oropharyngeal cancer: Dosimetric impact in the intensity modulated radiotherapy era. Head and Neck, 44(5), 1213-1222. https://doi.org/10.1002/hed.27021

@article{7c1a1ed3023649f7bb9bae307c1473eb,

title = "Submandibular gland transfer for the prevention of radiation-induced xerostomia in oropharyngeal cancer: Dosimetric impact in the intensity modulated radiotherapy era",

abstract = "Background: Submandibular gland (SMG) transfer decreased radiation-associated xerostomia in the 2/3-dimensional radiotherapy era. We evaluated the dosimetric implications of SMG transfer on modern intensity modulated radiotherapy (IMRT) plans. Methods: Eighteen oropharynx cancer patients underwent SMG transfer followed by IMRT; reoptimized plans using the baseline SMG location were generated. Mean salivary gland, oral cavity, and larynx doses were compared between clinical plans and reoptimized plans. Results: No statistically significant difference in mean SMG dose (27.53 Gy vs. 29.61 Gy) or total salivary gland dose (26.12 Gy vs. 26.41 Gy) was observed with or without SMG transfer (all p > 0.05). Mean oral cavity and larynx doses were not statistically different. Neither tumor site, target volume crossing midline, stage, nor salivary gland volumes were associated with mean doses. Conclusions: Salivary gland doses were similar with or without SMG transfer. IMRT likely decreases the benefit of SMG transfer on the risk of radiation-associated xerostomia.",

keywords = "IMRT, radiotherapy, submandibular gland, transfer surgery, xerostomia",

author = "Tugce Kutuk and McAllister, \{Nicole C.\} and Rzepczynski, \{Amy E.\} and Andre Williams and Geoffrey Young and Crawley, \{Meghan B.\} and Guilherme Rabinowits and Adeel Kaiser and Contreras, \{Jessika A.\} and Kalman, \{Noah S.\}",

note = "Funding Information: The preliminary results of this study has been submitted to the 63rd ASTRO Annual Meeting and accepted as a poster presentation. The authors appreciate Lisa Rosen for her assistance with a medical writing review. Publisher Copyright: {\textcopyright} 2022 Wiley Periodicals LLC.",

year = "2022",

month = may,

doi = "10.1002/hed.27021",

language = "English",

volume = "44",

pages = "1213--1222",

journal = "Head and Neck",

issn = "1043-3074",

number = "5",

}

Kutuk, T, McAllister, NC, Rzepczynski, AE, Williams, A, Young, G, Crawley, MB, Rabinowits, G, Kaiser, A, Contreras, JA & Kalman, NS 2022, 'Submandibular gland transfer for the prevention of radiation-induced xerostomia in oropharyngeal cancer: Dosimetric impact in the intensity modulated radiotherapy era', Head and Neck, vol. 44, no. 5, pp. 1213-1222. https://doi.org/10.1002/hed.27021

TY - JOUR

T1 - Submandibular gland transfer for the prevention of radiation-induced xerostomia in oropharyngeal cancer

T2 - Dosimetric impact in the intensity modulated radiotherapy era

AU - Kutuk, Tugce

AU - McAllister, Nicole C.

AU - Rzepczynski, Amy E.

AU - Williams, Andre

AU - Young, Geoffrey

AU - Crawley, Meghan B.

AU - Rabinowits, Guilherme

AU - Kaiser, Adeel

AU - Contreras, Jessika A.

AU - Kalman, Noah S.

N1 - Funding Information: The preliminary results of this study has been submitted to the 63rd ASTRO Annual Meeting and accepted as a poster presentation. The authors appreciate Lisa Rosen for her assistance with a medical writing review. Publisher Copyright: © 2022 Wiley Periodicals LLC.

PY - 2022/5

Y1 - 2022/5

N2 - Background: Submandibular gland (SMG) transfer decreased radiation-associated xerostomia in the 2/3-dimensional radiotherapy era. We evaluated the dosimetric implications of SMG transfer on modern intensity modulated radiotherapy (IMRT) plans. Methods: Eighteen oropharynx cancer patients underwent SMG transfer followed by IMRT; reoptimized plans using the baseline SMG location were generated. Mean salivary gland, oral cavity, and larynx doses were compared between clinical plans and reoptimized plans. Results: No statistically significant difference in mean SMG dose (27.53 Gy vs. 29.61 Gy) or total salivary gland dose (26.12 Gy vs. 26.41 Gy) was observed with or without SMG transfer (all p > 0.05). Mean oral cavity and larynx doses were not statistically different. Neither tumor site, target volume crossing midline, stage, nor salivary gland volumes were associated with mean doses. Conclusions: Salivary gland doses were similar with or without SMG transfer. IMRT likely decreases the benefit of SMG transfer on the risk of radiation-associated xerostomia.

AB - Background: Submandibular gland (SMG) transfer decreased radiation-associated xerostomia in the 2/3-dimensional radiotherapy era. We evaluated the dosimetric implications of SMG transfer on modern intensity modulated radiotherapy (IMRT) plans. Methods: Eighteen oropharynx cancer patients underwent SMG transfer followed by IMRT; reoptimized plans using the baseline SMG location were generated. Mean salivary gland, oral cavity, and larynx doses were compared between clinical plans and reoptimized plans. Results: No statistically significant difference in mean SMG dose (27.53 Gy vs. 29.61 Gy) or total salivary gland dose (26.12 Gy vs. 26.41 Gy) was observed with or without SMG transfer (all p > 0.05). Mean oral cavity and larynx doses were not statistically different. Neither tumor site, target volume crossing midline, stage, nor salivary gland volumes were associated with mean doses. Conclusions: Salivary gland doses were similar with or without SMG transfer. IMRT likely decreases the benefit of SMG transfer on the risk of radiation-associated xerostomia.

KW - IMRT

KW - radiotherapy

KW - submandibular gland

KW - transfer surgery

KW - xerostomia

UR - https://www.scopus.com/pages/publications/85125576489

U2 - 10.1002/hed.27021

DO - 10.1002/hed.27021

M3 - Article

C2 - 35243719

AN - SCOPUS:85125576489

SN - 1043-3074

VL - 44

SP - 1213

EP - 1222

JO - Head and Neck

JF - Head and Neck

IS - 5

ER -

Submandibular gland transfer for the prevention of radiation-induced xerostomia in oropharyngeal cancer: Dosimetric impact in the intensity modulated radiotherapy era

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