Subcutaneous panniculitic T-cell lymphoma in children: Response to combination therapy with cyclosporine and chemotherapy

Ayelet Shani-Adir, Anne W. Lucky, Julie Prendiville, Sharon Murphy, Murray Passo, Frederick S. Huang, Amy S. Paller

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

We describe 2 adolescent boys with facial swelling and/or subcutaneous nodules and fever. Extensive evaluation, including several biopsy specimens, led to a diagnosis of subcutaneous panniculitic T-cell lymphoma, an entity rarely seen in children. Both patients were treated with oral cyclosporine in an effort to suppress the cytokine release from T-cells that has been thought to induce the hemophagocytic syndrome. The patients responded dramatically to cyclosporine treatment with defervescence of the fever and reduction in number and size of the subcutaneous nodules. Subsequent therapy with multidrug chemotherapy achieved complete remission in the first patient. This report suggests the value of cyclosporine as a first-line agent coupled with chemotherapy in the treatment of patients with subcutaneous panniculitic T-cell lymphoma. A clinicopathologic review of 8 described pediatric cases of subcutaneous panniculitic T-cell lymphoma is also presented.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume50
Issue number2 SUPPL.
StatePublished - Feb 2004
Externally publishedYes

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