Subacute ascending numbness

B. Arshi, S. Shaw

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A 21-year-old male presented with two weeks of ascending numbness involving all 4 limbs, and imbalance when walking. Examination revealed diminished vibration and proprioception at the fingers, toes, and ankles, a high steppage gait and a positive Romberg sign. He had no weakness in any muscle groups. Laboratory data included vitamin B12 218 pg/mL (normal range: 200-800 pg/mL), homocysteine 87 μmol/L (normal range: 2.2-13.2 μmol/L), and non-reactive RPR. Magnetic resonance imaging of the cervical spine revealed abnormal T2-weighted hyperintensity along the posterior columns extending from C2 to C7.

Original languageEnglish
Pages (from-to)905-906
Number of pages2
JournalClinical Toxicology
Issue number8
StatePublished - Sep 1 2014


  • CNS and psychological
  • CNS/Psychological
  • Metabolic


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