TY - JOUR
T1 - Study protocol
T2 - MyoFit46—the cardiac sub-study of the MRC National Survey of Health and Development
AU - Webber, Matthew
AU - Falconer, Debbie
AU - AlFarih, Mashael
AU - Joy, George
AU - Chan, Fiona
AU - Davie, Clare
AU - Hamill Howes, Lee
AU - Wong, Andrew
AU - Rapala, Alicja
AU - Bhuva, Anish
AU - Davies, Rhodri H.
AU - Morton, Christopher
AU - Aguado-Sierra, Jazmin
AU - Vazquez, Mariano
AU - Tao, Xuyuan
AU - Krausz, Gunther
AU - Tanackovic, Slobodan
AU - Guger, Christoph
AU - Xue, Hui
AU - Kellman, Peter
AU - Pierce, Iain
AU - Schott, Jonathan
AU - Hardy, Rebecca
AU - Chaturvedi, Nishi
AU - Rudy, Yoram
AU - Moon, James C.
AU - Lambiase, Pier D.
AU - Orini, Michele
AU - Hughes, Alun D.
AU - Captur, Gabriella
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: The life course accumulation of overt and subclinical myocardial dysfunction contributes to older age mortality, frailty, disability and loss of independence. The Medical Research Council National Survey of Health and Development (NSHD) is the world’s longest running continued surveillance birth cohort providing a unique opportunity to understand life course determinants of myocardial dysfunction as part of MyoFit46–the cardiac sub-study of the NSHD. Methods: We aim to recruit 550 NSHD participants of approximately 75 years+ to undertake high-density surface electrocardiographic imaging (ECGI) and stress perfusion cardiovascular magnetic resonance (CMR). Through comprehensive myocardial tissue characterization and 4-dimensional flow we hope to better understand the burden of clinical and subclinical cardiovascular disease. Supercomputers will be used to combine the multi-scale ECGI and CMR datasets per participant. Rarely available, prospectively collected whole-of-life data on exposures, traditional risk factors and multimorbidity will be studied to identify risk trajectories, critical change periods, mediators and cumulative impacts on the myocardium. Discussion: By combining well curated, prospectively acquired longitudinal data of the NSHD with novel CMR–ECGI data and sharing these results and associated pipelines with the CMR community, MyoFit46 seeks to transform our understanding of how early, mid and later-life risk factor trajectories interact to determine the state of cardiovascular health in older age. Trial registration: Prospectively registered on ClinicalTrials.gov with trial ID: 19/LO/1774 Multimorbidity Life-Course Approach to Myocardial Health- A Cardiac Sub-Study of the MCRC National Survey of Health and Development (NSHD).
AB - Background: The life course accumulation of overt and subclinical myocardial dysfunction contributes to older age mortality, frailty, disability and loss of independence. The Medical Research Council National Survey of Health and Development (NSHD) is the world’s longest running continued surveillance birth cohort providing a unique opportunity to understand life course determinants of myocardial dysfunction as part of MyoFit46–the cardiac sub-study of the NSHD. Methods: We aim to recruit 550 NSHD participants of approximately 75 years+ to undertake high-density surface electrocardiographic imaging (ECGI) and stress perfusion cardiovascular magnetic resonance (CMR). Through comprehensive myocardial tissue characterization and 4-dimensional flow we hope to better understand the burden of clinical and subclinical cardiovascular disease. Supercomputers will be used to combine the multi-scale ECGI and CMR datasets per participant. Rarely available, prospectively collected whole-of-life data on exposures, traditional risk factors and multimorbidity will be studied to identify risk trajectories, critical change periods, mediators and cumulative impacts on the myocardium. Discussion: By combining well curated, prospectively acquired longitudinal data of the NSHD with novel CMR–ECGI data and sharing these results and associated pipelines with the CMR community, MyoFit46 seeks to transform our understanding of how early, mid and later-life risk factor trajectories interact to determine the state of cardiovascular health in older age. Trial registration: Prospectively registered on ClinicalTrials.gov with trial ID: 19/LO/1774 Multimorbidity Life-Course Approach to Myocardial Health- A Cardiac Sub-Study of the MCRC National Survey of Health and Development (NSHD).
KW - 4-dimensional flow
KW - Cardiovascular health
KW - Cardiovascular magnetic resonance
KW - Electrocardiographic imaging
KW - Life course risk factors
KW - Myocardial tissue characterization
KW - Perfusion
KW - Risk trajectories
KW - Subclinical myocardial dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85127402665&partnerID=8YFLogxK
U2 - 10.1186/s12872-022-02582-0
DO - 10.1186/s12872-022-02582-0
M3 - Article
C2 - 35365075
AN - SCOPUS:85127402665
SN - 1471-2261
VL - 22
JO - BMC Cardiovascular Disorders
JF - BMC Cardiovascular Disorders
IS - 1
M1 - 140
ER -