Estudio de variantes de los genes BDNF, COMT, DAT1 y SERT en niños colombianos con déficit de atención

Translated title of the contribution: Study of genetic variants in the BDNF, COMT, DAT1 and SERT genes in Colombian children with attention deficit disorder

Jenny Ortega-Rojas, Carlos E. Arboleda-Bustos, Luis Morales, Bruno A. Benítez, Diana Beltrán, Álvaro Izquierdo, Humberto Arboleda, Rafael Vásquez

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background Attention deficit and hyperactive disorder (ADHD) is highly prevalent among children in Bogota City. Both genetic and environmental factors play a very important role in the etiology of ADHD. However, to date few studies have addressed the association of genetic variants and ADHD in the Colombian population. Objectives To test the genetic association between polymorphisms in the DAT1, HTTLPR, COMT and BDNF genes and ADHD in a sample from Bogota City. Methods We genotyped the most common polymorphisms in DAT1, SERT, COMT and BDNF genes associated with ADHD using conventional PCR followed by restriction fragment length polymorphism (RFLP) in 97 trios recruited in a medical center in Bogota. The transmission disequilibrium test (TDT) was used to determine the association between such genetic variants and ADHD. Results The TDT analysis showed that no individual allele of any variant studied has a preferential transmission. Conclusions Our results suggest that the etiology of the ADHD may be complex and involves several genetic factors. Further studies in other candidate polymorphisms in a larger sample size will improve our knowledge of the ADHD in Colombian population.

Translated title of the contributionStudy of genetic variants in the BDNF, COMT, DAT1 and SERT genes in Colombian children with attention deficit disorder
Original languageSpanish
Pages (from-to)222-228
Number of pages7
JournalRevista Colombiana de Psiquiatria
Volume46
Issue number4
DOIs
StatePublished - Oct 2017

Keywords

  • ADHD
  • Colombia
  • Polymorphisms
  • TDT

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