Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser: Insight into the possible inactivation mechanisms

Kong T. Tsen; Shaw Wei D. Tsen; Qiang Fu; Stuart M. Lindsay; Zhe Li; Stephanie Cope; Sara Vaiana; Juliann G. Kiang

doi:10.1117/1.3600771

Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser: Insight into the possible inactivation mechanisms

Kong T. Tsen
, Shaw Wei D. Tsen
, Qiang Fu
, Stuart M. Lindsay
, Zhe Li
, Stephanie Cope
, Sara Vaiana
, Juliann G. Kiang

Biophotonics Research Center

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

We report experimental results on the inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by a visible femtosecond laser. Our results suggest that inactivation of virus and bacterium by a visible femtosecond laser involves completely different mechanisms. Inactivation of viruses by a visible femtosecond laser involves the breaking of hydrogen/hydrophobic bonds or the separation of the weak protein links in the protein shell of a viral particle. In contrast, inactivation of bacteria is related to the damage of their DNAs due to irradiation of a visible femtosecond laser. Possible mechanisms for the inactivation of viruses and bacteria are discussed.

Original language	English
Article number	078003
Journal	Journal of biomedical optics
Volume	16
Issue number	7
DOIs	https://doi.org/10.1117/1.3600771
State	Published - Jul 2011

Keywords

Bacteria
Femtosecond lasers
Inactivation of viruses
Irradiation

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10.1117/1.3600771

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Tsen, K. T., Tsen, S. W. D., Fu, Q., Lindsay, S. M., Li, Z., Cope, S., Vaiana, S., & Kiang, J. G. (2011). Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser: Insight into the possible inactivation mechanisms. Journal of biomedical optics, 16(7), Article 078003. https://doi.org/10.1117/1.3600771

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title = "Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser: Insight into the possible inactivation mechanisms",

abstract = "We report experimental results on the inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by a visible femtosecond laser. Our results suggest that inactivation of virus and bacterium by a visible femtosecond laser involves completely different mechanisms. Inactivation of viruses by a visible femtosecond laser involves the breaking of hydrogen/hydrophobic bonds or the separation of the weak protein links in the protein shell of a viral particle. In contrast, inactivation of bacteria is related to the damage of their DNAs due to irradiation of a visible femtosecond laser. Possible mechanisms for the inactivation of viruses and bacteria are discussed.",

keywords = "Bacteria, Femtosecond lasers, Inactivation of viruses, Irradiation",

author = "Tsen, \{Kong T.\} and Tsen, \{Shaw Wei D.\} and Qiang Fu and Lindsay, \{Stuart M.\} and Zhe Li and Stephanie Cope and Sara Vaiana and Kiang, \{Juliann G.\}",

note = "Funding Information: This work was supported by the National Science Foundation. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, or the U.S. Department of Defense.",

year = "2011",

month = jul,

doi = "10.1117/1.3600771",

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journal = "Journal of biomedical optics",

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Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser: Insight into the possible inactivation mechanisms. / Tsen, Kong T.; Tsen, Shaw Wei D.; Fu, Qiang et al.
In: Journal of biomedical optics, Vol. 16, No. 7, 078003, 07.2011.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser

T2 - Insight into the possible inactivation mechanisms

AU - Tsen, Kong T.

AU - Tsen, Shaw Wei D.

AU - Fu, Qiang

AU - Lindsay, Stuart M.

AU - Li, Zhe

AU - Cope, Stephanie

AU - Vaiana, Sara

AU - Kiang, Juliann G.

N1 - Funding Information: This work was supported by the National Science Foundation. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, or the U.S. Department of Defense.

PY - 2011/7

Y1 - 2011/7

N2 - We report experimental results on the inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by a visible femtosecond laser. Our results suggest that inactivation of virus and bacterium by a visible femtosecond laser involves completely different mechanisms. Inactivation of viruses by a visible femtosecond laser involves the breaking of hydrogen/hydrophobic bonds or the separation of the weak protein links in the protein shell of a viral particle. In contrast, inactivation of bacteria is related to the damage of their DNAs due to irradiation of a visible femtosecond laser. Possible mechanisms for the inactivation of viruses and bacteria are discussed.

AB - We report experimental results on the inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by a visible femtosecond laser. Our results suggest that inactivation of virus and bacterium by a visible femtosecond laser involves completely different mechanisms. Inactivation of viruses by a visible femtosecond laser involves the breaking of hydrogen/hydrophobic bonds or the separation of the weak protein links in the protein shell of a viral particle. In contrast, inactivation of bacteria is related to the damage of their DNAs due to irradiation of a visible femtosecond laser. Possible mechanisms for the inactivation of viruses and bacteria are discussed.

KW - Bacteria

KW - Femtosecond lasers

KW - Inactivation of viruses

KW - Irradiation

UR - https://www.scopus.com/pages/publications/80455137190

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DO - 10.1117/1.3600771

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SN - 1083-3668

VL - 16

JO - Journal of biomedical optics

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M1 - 078003

ER -

Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser: Insight into the possible inactivation mechanisms

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