TY - CHAP
T1 - Studies of Glial Glutamate Transporters in Hippocampal Microcultures
AU - Mennerick, Steven
AU - Cormier, Robert J.
AU - Zorumski, Charles F.
N1 - Publisher Copyright:
© 2002 by Wiley-Liss, Inc., Hoboken, New Jersey.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Glutamate transporters are vital for shaping synaptic excitation and for maintaining ambient glutamate concentrations below excitotoxic levels. Because plasma-membrane glutamate transporters flux and transport ions, they can be studied with high temporal resolution using electrophysiological techniques. We review some applications of electrophysiology to the study of glutamate transporter kinetics. We concentrate on our own studies of glutamate transport by astrocytes during synaptic transmission on hippocampal microcultures, a preparation that offers a high degree of experimental control over the synaptic environment.
AB - Glutamate transporters are vital for shaping synaptic excitation and for maintaining ambient glutamate concentrations below excitotoxic levels. Because plasma-membrane glutamate transporters flux and transport ions, they can be studied with high temporal resolution using electrophysiological techniques. We review some applications of electrophysiology to the study of glutamate transporter kinetics. We concentrate on our own studies of glutamate transport by astrocytes during synaptic transmission on hippocampal microcultures, a preparation that offers a high degree of experimental control over the synaptic environment.
UR - http://www.scopus.com/inward/record.url?scp=85218045988&partnerID=8YFLogxK
U2 - 10.1002/0471434043.ch14
DO - 10.1002/0471434043.ch14
M3 - Chapter
AN - SCOPUS:85218045988
SN - 9780471065135
SP - 217
EP - 238
BT - Transmembrane Transporters
PB - wiley
ER -