Studies in Persons at Risk for Huntington's Disease

M. R. Hayden; J. Hewitt; W. R.W. Martin; C. Clark; W. Ammann; Joel S. Perlmutter; Marcus E. Raichle; Jeffrey D. Seidman; John C. Mazziotta; Michael E. Phelps; Jorgj Pahl; Sung Cheng Huang; Lewis R. Baxter; John M. Hoffman; Charles H. Markham; Walter H. Riege; Andrew B. Lanto; Joseph A. Wapenski

doi:10.1056/NEJM198708063170612

Studies in Persons at Risk for Huntington's Disease

M. R. Hayden, J. Hewitt, W. R.W. Martin, C. Clark, W. Ammann, Joel S. Perlmutter, Marcus E. Raichle, Jeffrey D. Seidman, John C. Mazziotta, Michael E. Phelps, Jorgj Pahl, Sung Cheng Huang, Lewis R. Baxter, John M. Hoffman, Charles H. Markham, Walter H. Riege, Andrew B. Lanto, Joseph A. Wapenski

Research output: Contribution to journal › Letter › peer-review

18 Scopus citations

Abstract

To the Editor: The report by Mazziotta et al. (Feb. 12 issue)¹ shows that caudate glucose metabolism is reduced in some asymptomatic subjects at risk for Huntington's disease. At present, however, it is unknown which members of their at-risk population are likely to have inherited the abnormal gene. We have studied 23 persons at risk for Huntington's disease, using positron emission tomography (PET) with the fluorodeoxy-glucose tracer analogue and a polymorphic human DNA marker linked to the gene for Huntington's disease.² ³ ⁴ After analysis of four large families, we were able to determine clearly the likelihood of inheritance of the gene…

Original language	English
Pages (from-to)	382-384
Number of pages	3
Journal	New England Journal of Medicine
Volume	317
Issue number	6
DOIs	https://doi.org/10.1056/NEJM198708063170612
State	Published - Aug 6 1987

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Hayden, M. R., Hewitt, J., Martin, W. R. W., Clark, C., Ammann, W., Perlmutter, J. S., Raichle, M. E., Seidman, J. D., Mazziotta, J. C., Phelps, M. E., Pahl, J., Huang, S. C., Baxter, L. R., Hoffman, J. M., Markham, C. H., Riege, W. H., Lanto, A. B., & Wapenski, J. A. (1987). Studies in Persons at Risk for Huntington's Disease. New England Journal of Medicine, 317(6), 382-384. https://doi.org/10.1056/NEJM198708063170612

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title = "Studies in Persons at Risk for Huntington's Disease",

abstract = "To the Editor: The report by Mazziotta et al. (Feb. 12 issue)1 shows that caudate glucose metabolism is reduced in some asymptomatic subjects at risk for Huntington's disease. At present, however, it is unknown which members of their at-risk population are likely to have inherited the abnormal gene. We have studied 23 persons at risk for Huntington's disease, using positron emission tomography (PET) with the fluorodeoxy-glucose tracer analogue and a polymorphic human DNA marker linked to the gene for Huntington's disease.2 3 4 After analysis of four large families, we were able to determine clearly the likelihood of inheritance of the gene…",

author = "Hayden, {M. R.} and J. Hewitt and Martin, {W. R.W.} and C. Clark and W. Ammann and Perlmutter, {Joel S.} and Raichle, {Marcus E.} and Seidman, {Jeffrey D.} and Mazziotta, {John C.} and Phelps, {Michael E.} and Jorgj Pahl and Huang, {Sung Cheng} and Baxter, {Lewis R.} and Hoffman, {John M.} and Markham, {Charles H.} and Riege, {Walter H.} and Lanto, {Andrew B.} and Wapenski, {Joseph A.}",

year = "1987",

month = aug,

day = "6",

doi = "10.1056/NEJM198708063170612",

language = "English",

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Hayden, MR, Hewitt, J, Martin, WRW, Clark, C, Ammann, W, Perlmutter, JS , Raichle, ME, Seidman, JD, Mazziotta, JC, Phelps, ME, Pahl, J, Huang, SC, Baxter, LR, Hoffman, JM, Markham, CH, Riege, WH, Lanto, AB & Wapenski, JA 1987, 'Studies in Persons at Risk for Huntington's Disease', New England Journal of Medicine, vol. 317, no. 6, pp. 382-384. https://doi.org/10.1056/NEJM198708063170612

TY - JOUR

T1 - Studies in Persons at Risk for Huntington's Disease

AU - Hayden, M. R.

AU - Hewitt, J.

AU - Martin, W. R.W.

AU - Clark, C.

AU - Ammann, W.

AU - Perlmutter, Joel S.

AU - Raichle, Marcus E.

AU - Seidman, Jeffrey D.

AU - Mazziotta, John C.

AU - Phelps, Michael E.

AU - Pahl, Jorgj

AU - Huang, Sung Cheng

AU - Baxter, Lewis R.

AU - Hoffman, John M.

AU - Markham, Charles H.

AU - Riege, Walter H.

AU - Lanto, Andrew B.

AU - Wapenski, Joseph A.

PY - 1987/8/6

Y1 - 1987/8/6

N2 - To the Editor: The report by Mazziotta et al. (Feb. 12 issue)1 shows that caudate glucose metabolism is reduced in some asymptomatic subjects at risk for Huntington's disease. At present, however, it is unknown which members of their at-risk population are likely to have inherited the abnormal gene. We have studied 23 persons at risk for Huntington's disease, using positron emission tomography (PET) with the fluorodeoxy-glucose tracer analogue and a polymorphic human DNA marker linked to the gene for Huntington's disease.2 3 4 After analysis of four large families, we were able to determine clearly the likelihood of inheritance of the gene…

AB - To the Editor: The report by Mazziotta et al. (Feb. 12 issue)1 shows that caudate glucose metabolism is reduced in some asymptomatic subjects at risk for Huntington's disease. At present, however, it is unknown which members of their at-risk population are likely to have inherited the abnormal gene. We have studied 23 persons at risk for Huntington's disease, using positron emission tomography (PET) with the fluorodeoxy-glucose tracer analogue and a polymorphic human DNA marker linked to the gene for Huntington's disease.2 3 4 After analysis of four large families, we were able to determine clearly the likelihood of inheritance of the gene…

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U2 - 10.1056/NEJM198708063170612

DO - 10.1056/NEJM198708063170612

M3 - Letter

C2 - 2955223

AN - SCOPUS:0023260742

SN - 0028-4793

VL - 317

SP - 382

EP - 384

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 6

ER -

Studies in Persons at Risk for Huntington's Disease

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