Sts map of genes and anonymous dna fragments on human chromosome 18 using a panel of somatic cell hybrids

Joan Overhauser, Reema Mewar, Katherine Rojas, Kisten Lia, Antonie D. Kline, Gary A. Silverman

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Somatic cell hybrids containing different deleted regions of chromosome 18 derived from patients with balanced translocations or terminal deletions were used to create a deletion mapping panel. Twenty-four sequence-tagged sites (STSs) for 17 genes and 7 anonymous polymorphic DNA fragments were identified. These STSs were used to map the 24 loci to 18 defined regions of chromosome 18. Both ERV1, previously mapped to 18q22-q23, and YES1, previously mapped to 18q21.3, were found to map to 18p11.21-pter. Several genes previously mapped to 18q21 were found to be in the order cen-SSAV1-DCC-FECH-GRP-BCL2-PLANH2-tel. The precise mapping of genes to chromosome 18 should help in determining whether these genes may be involved in the etiology of specific chromosomal syndromes associated with chromosome 18. The mapping of the polymorphic loci will assist in the integration of the physical map with the recombination map of chromosome 18.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalGenomics
Volume15
Issue number2
DOIs
StatePublished - Feb 1993
Externally publishedYes

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