Structure of the DNA binding domain of E. coli SSB bound to ssDNA

Srinivasan Raghunathan; Alexander G. Kozlov; Timothy M. Lohman; Gabriel Waksman

doi:10.1038/77943

Structure of the DNA binding domain of E. coli SSB bound to ssDNA

Srinivasan Raghunathan, Alexander G. Kozlov, Timothy M. Lohman, Gabriel Waksman

Biochemistry and Molecular Biophysics

Research output: Contribution to journal › Article › peer-review

329 Scopus citations

Abstract

The structure of the homotetrameric DNA binding domain of the single stranded DNA binding protein from Escherichia coil (Eco SSB) bound to two 35-mer single stranded DNAs was determined to a resolution of 2.8 Å. This structure describes the vast network of interactions that results in the extensive wrapping of single stranded DNA around the SSB tetramer and suggests a structural basis for its various binding modes.

Original language	English
Pages (from-to)	648-652
Number of pages	5
Journal	Nature Structural Biology
Volume	7
Issue number	8
DOIs	https://doi.org/10.1038/77943
State	Published - Aug 1 2000

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title = "Structure of the DNA binding domain of E. coli SSB bound to ssDNA",

abstract = "The structure of the homotetrameric DNA binding domain of the single stranded DNA binding protein from Escherichia coil (Eco SSB) bound to two 35-mer single stranded DNAs was determined to a resolution of 2.8 {\AA}. This structure describes the vast network of interactions that results in the extensive wrapping of single stranded DNA around the SSB tetramer and suggests a structural basis for its various binding modes.",

author = "Srinivasan Raghunathan and Kozlov, {Alexander G.} and Lohman, {Timothy M.} and Gabriel Waksman",

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