Structure of the DNA binding domain of E. coli SSB bound to ssDNA

Srinivasan Raghunathan, Alexander G. Kozlov, Timothy M. Lohman, Gabriel Waksman

Research output: Contribution to journalArticlepeer-review

356 Scopus citations


The structure of the homotetrameric DNA binding domain of the single stranded DNA binding protein from Escherichia coil (Eco SSB) bound to two 35-mer single stranded DNAs was determined to a resolution of 2.8 Å. This structure describes the vast network of interactions that results in the extensive wrapping of single stranded DNA around the SSB tetramer and suggests a structural basis for its various binding modes.

Original languageEnglish
Pages (from-to)648-652
Number of pages5
JournalNature Structural Biology
Issue number8
StatePublished - Aug 2000


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