Structure of the carbohydrate units of IgA1 immunoglobulin. II. Structure of the O glycosidically linked oligosaccharide units

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Abstract

In a preceding paper the structure of the 2 asparagine linked oligosaccharide units of an IgA1 myeloma protein was defined. In this paper data are presented which establish the structure and linkage points of the 5 O glycosidically linked oligosaccharide units found on the α1 subtype heavy chain. This structure appears to be identical with that which the authors have determined for the hinge region glycopeptide isolated by Frangione and Wolfenstein Todel, from a different IgA1 myeloma protein. This region is deleted in the α2 subtype of IgA. Aside from the presence of a terminal N acetylgalactosamine at the NH2 terminus, the location and structure of the 5 O glycosidically linked oligosaccharide units of the glycopeptide preserve the symmetry observed by Frangione and Wolfenstein Todel to be present in the amino acid sequence of the hinge region.

Original languageEnglish
Pages (from-to)7270-7281
Number of pages12
JournalJournal of Biological Chemistry
Volume249
Issue number22
StatePublished - Dec 1 1974

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